Potentially diagnostic and prognostic roles of piRNAs/PIWIs in pancreatic cancer: A review

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-12 DOI:10.1016/j.bbcan.2025.189286

Yukun Liu , Changlei Li , Xiaotong Cui , Miaomiao Li , Shiguo Liu , Zusen Wang

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引用次数: 0

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited early diagnostic methods and therapeutic options, contributing to its poor prognosis. Recent advances in high-throughput sequencing have highlighted the critical roles of noncoding RNAs (ncRNAs), particularly PIWI-interacting RNAs (piRNAs), in cancer biology. In this review, we systematically summarize the emerging roles of piRNAs and their associated PIWI proteins in PDAC pathogenesis, progression, and prognosis. We provide a comprehensive analysis of the molecular mechanisms by which piRNAs/PIWIs regulate gene expression and cellular signaling pathways in PDAC. Furthermore, we discuss their potential as novel biomarkers for early diagnosis and therapeutic targets. Importantly, this review identifies key piRNAs/PIWIs involved in PDAC and proposes innovative strategies for improving diagnosis and treatment outcomes. Our work not only consolidates current knowledge but also offers new perspectives for future research and clinical applications in PDAC management.

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pirna / piwi在胰腺癌中的潜在诊断和预后作用：综述

胰腺导管腺癌（Pancreatic ductal adencarcinoma， PDAC）是一种高度侵袭性的恶性肿瘤，早期诊断方法和治疗选择有限，导致其预后较差。高通量测序的最新进展突出了非编码rna (ncRNAs)，特别是piwi相互作用rna （piRNAs）在癌症生物学中的关键作用。在这篇综述中，我们系统地总结了pirna及其相关PIWI蛋白在PDAC发病、进展和预后中的新作用。我们对PDAC中pirna / piwi调控基因表达和细胞信号通路的分子机制进行了全面分析。此外，我们还讨论了它们作为早期诊断和治疗靶点的新型生物标志物的潜力。重要的是，本综述确定了PDAC中涉及的关键pirna / piwi，并提出了改善诊断和治疗结果的创新策略。我们的工作不仅巩固了现有的知识，而且为PDAC管理的未来研究和临床应用提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.