Sequential Knee and Hip Arthroplasty in a Patient With Pfeifer-Weber-Christian Disease

IF 1.5 Q3 ORTHOPEDICS

Arthroplasty Today Pub Date : 2025-02-17 DOI:10.1016/j.artd.2025.101637

Edgar Barros Prieto MD , Eduardo Noboa Freile MD , Carlos Peñaherrera Carillo MD , Francisco Endara Urresta MD , Alejandro Barros Castro MD , Paul Vaca Perez MD

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引用次数: 0

Abstract

Pfeifer-Weber-Christian Disease (PWCD) is a rare chronic inflammatory condition characterized by recurrent painful subcutaneous nodules and systemic manifestations. Long-term corticosteroid therapy, essential for managing PWCD, predisposes patients to complications such as osteoarthritis and avascular necrosis, often necessitating joint replacement surgeries. This report discusses a 38-year-old woman with a 15-year history of PWCD who underwent sequential knee and hip arthroplasty due to severe joint degeneration. The patient presented with debilitating pain, significant functional impairment, and advanced degenerative changes in the left knee and right hip. A multidisciplinary team provided comprehensive perioperative care to address the complexities of chronic inflammation, immunosuppression, and poor bone quality. This case highlights the feasibility of joint replacement in PWCD patients when a multidisciplinary approach and meticulous planning are applied. It underscores the importance of individualized surgical strategies and extended follow-up to optimize outcomes in complex cases.

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Pfeifer-Weber-Christian疾病患者的顺序膝关节和髋关节置换术

Pfeifer-Weber-Christian病（PWCD）是一种罕见的慢性炎症性疾病，其特征是反复出现疼痛的皮下结节和全身表现。长期皮质类固醇治疗对于治疗PWCD至关重要，但会使患者容易出现骨关节炎和缺血性坏死等并发症，通常需要进行关节置换手术。本报告讨论了一位38岁的女性，她有15年的PWCD病史，由于严重的关节退变，她接受了连续的膝关节和髋关节置换术。患者表现为使人衰弱的疼痛、明显的功能损害以及左膝和右髋关节的晚期退行性改变。一个多学科的团队提供了全面的围手术期护理，以解决慢性炎症、免疫抑制和骨质量差的复杂性。本病例强调了关节置换术在多学科联合治疗和精心规划下的可行性。它强调了个性化手术策略和延长随访的重要性，以优化复杂病例的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthroplasty Today Medicine-Surgery

CiteScore

2.90

自引率

0.00%

发文量

258

审稿时长

40 weeks

期刊介绍： Arthroplasty Today is a companion journal to the Journal of Arthroplasty. The journal Arthroplasty Today brings together the clinical and scientific foundations for joint replacement of the hip and knee in an open-access, online format. Arthroplasty Today solicits manuscripts of the highest quality from all areas of scientific endeavor that relate to joint replacement or the treatment of its complications, including those dealing with patient outcomes, economic and policy issues, prosthetic design, biomechanics, biomaterials, and biologic response to arthroplasty. The journal focuses on case reports. It is the purpose of Arthroplasty Today to present material to practicing orthopaedic surgeons that will keep them abreast of developments in the field, prove useful in the care of patients, and aid in understanding the scientific foundation of this subspecialty area of joint replacement. The international members of the Editorial Board provide a worldwide perspective for the journal''s area of interest. Their participation ensures that each issue of Arthroplasty Today provides the reader with timely, peer-reviewed articles of the highest quality.