A Mild Reductant NHC‐ligated Borane for N‑Formylation of Amines with CO2 under Ambient Conditions

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-02-15 DOI:10.1002/adsc.202401384

Wangyu Li, Shiwen Zhou, He Tang, Fengjian Chu, Hongru Feng, Yuan-Jiang Pan

引用次数: 0

Abstract

A convenient and efficient metal‐free protocol has been reported for formylation of various amines with carbon dioxide. This reaction could proceed under ambient conditions and show a broad substrate scope, encompassing primary amines, secondary amines, chiral amino acid esters and bioactive molecules. Furthermore, this method offers several advantages, including the preservation of substrate chirality, ease of separation and purification and the suitability of formic acid and formate salts as reactants in this reaction.

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一种温和的 NHC 配位硼烷还原剂，用于在环境条件下用 CO2 对胺进行 N-甲酰化反应

据报道，一种便捷高效的无金属方案可用于各种胺与二氧化碳的甲酰化反应。该反应可在环境条件下进行，底物范围广泛，包括伯胺、仲胺、手性氨基酸酯和生物活性分子。此外，这种方法还具有一些优点，包括可以保持底物的手性、易于分离和纯化，以及适合将甲酸和甲酸盐作为该反应的反应物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.