{"title":"Bioderived Polyarylester Nanofilms from Innovative Plant Materials for High-Efficient Organic Solvent Nanofiltration.","authors":"Zihao Liu, Yingjie Huang, Yanfeng Lv, Yushun Zhou, Kang Wang, Hui Zhao","doi":"10.1021/acsami.4c19244","DOIUrl":null,"url":null,"abstract":"<p><p>The successful realization of thin film composite (TFC) organic solvent nanofiltration (OSN) membranes with high permeability and small solute selectivity for solute-solute separation to purify drugs in complex solution environments remains challenging in the pharmaceutical industry. Here, we present the preparation of high cross-linked TFC OSN membranes via interfacial polymerization (IP) utilizing phlorotannin, a plant-derived biomass phenolic compound, as a promising aqueous phase monomer. Benefiting from the presence of multiple cross-linking sites and twisted rigid structure in phlorotannin, nanofiltration membranes with excellent molecular selectivity and solvent permeability were successfully fabricated. This allowed for straightforward separation and purification of active pharmaceutical ingredients from intermediates. The membranes demonstrated remarkable stability over extended periods of operation and adaptability to a diverse array of solvent environments, making them a highly promising option for use in fine chemicals, biopharmaceuticals, and other fields.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":"14477-14487"},"PeriodicalIF":8.3000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsami.4c19244","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The successful realization of thin film composite (TFC) organic solvent nanofiltration (OSN) membranes with high permeability and small solute selectivity for solute-solute separation to purify drugs in complex solution environments remains challenging in the pharmaceutical industry. Here, we present the preparation of high cross-linked TFC OSN membranes via interfacial polymerization (IP) utilizing phlorotannin, a plant-derived biomass phenolic compound, as a promising aqueous phase monomer. Benefiting from the presence of multiple cross-linking sites and twisted rigid structure in phlorotannin, nanofiltration membranes with excellent molecular selectivity and solvent permeability were successfully fabricated. This allowed for straightforward separation and purification of active pharmaceutical ingredients from intermediates. The membranes demonstrated remarkable stability over extended periods of operation and adaptability to a diverse array of solvent environments, making them a highly promising option for use in fine chemicals, biopharmaceuticals, and other fields.
期刊介绍：
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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