Association of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) and Neurogenesis: A Systematic Review.

IF 2.6 4区医学 Q3 NEUROSCIENCES

Acta Neuropsychiatrica Pub Date : 2025-02-14 DOI:10.1017/neu.2025.4

Hezekiah C T Au, Yang Jing Zheng, Gia Han Le, Sabrina Wong, Kayla M Teopiz, Angela T H Kwan, Hartej Gill, Sebastian Badulescu, Kyle Valentino, Joshua D Rosenblat, Rodrigo B Mansur, Roger S McIntyre

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引用次数: 0

Abstract

Objective: Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) administration has been associated with neuroproliferative effects and modulatory effects in neuronal pathways. Herein, we conducted a comprehensive synthesis of the effects of GLP-1 and GLP-1 RAs on neurogenesis.

Methods: We examined studies that investigate changes in neurogenesis mediated by GLP-1 and GLP-1 RA administration in both human and animal populations. Relevant articles were retrieved through OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to July 2nd. Primary studies investigating the role of GLP-1 and GLP-1 RAs on neurogenesis were included for analysis.

Results: GLP-1 and GLP-1 RAs (i.e. exenatide, geniposide, liraglutide, lixisenatide, and semaglutide), increased neurogenesis within the dentate gyrus, hippocampus, olfactory bulb, and the medial striatum in animal models. Additionally, GLP-1 and GLP-1 RAs were associated with modulating changes in multiple apoptotic pathways and upregulating survival pathways.

Discussion: GLP-1 and GLP-1 RAs are positively associated with neurogenesis. This effect may have translational implications insofar as disparate mental disorders that are characterized by neurogenesis defects (e.g. depressive disorders and neurocognitive disorders) may be benefitted by these agents.

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来源期刊

Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY

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5.30%

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期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.