{"title":"Study on thyroid autoimmunity of oral lichen planus and oral lichenoid mucositis.","authors":"C Lavanya, K Ranganathan","doi":"10.4103/jomfp.jomfp_85_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Oral lichen planus (OLP) and oral lichenoid mucositis (OLM) are immune-mediated mucosal conditions with multifactorial etiology, with similar clinical and histological characteristics. Diagnosis should be confirmed considering both clinical and histological aspects. Some subsets are associated with immune-mediated thyroid dysfunction due to anti-thyroid peroxidase antibody (TPO) and anti-thyroglobulin antibody (TGA).</p><p><strong>Aims: </strong>To ascertain the presence of thyroid autoantibodies in a cohort of patients with OLP and OLM from a South Indian population.</p><p><strong>Methods and materials: </strong>This observational study comprised 21 patients with 7 cases of OLP (Group I) and 14 cases of OLM (Group II) who reported from 2021-2023 for 2 years. Serum anti-thyroid antibodies including TPO and TGA was estimated using chemiluminescence immunoassay technique along with clinical and histological aspects. Altered levels of serological parameters were compared with respect to these auto-immune conditions.</p><p><strong>Results: </strong>Increased level of thyroid autoantibodies was observed in three (42%) of the seven cases of OLP. Two cases had elevated TPO (3-4 folds) and TGA (6-38 folds) and the subjects were above 50 years. Seven (50%) of the 14 OLM cases exhibited increased thyroid autoantibody levels and were above 50 years, predominantly females. TPO levels were increased in the range of 12 to 178 and TGA from 2 to 136 folds. Duration of these lesions were more than a year.</p><p><strong>Conclusions: </strong>Increased thyroid autoantibodies observed in both OLP and OLM represent an underlying autoimmune response. Long-term monitoring will enable the clinicians to correlate the antibody levels with the management of these lesions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"549-554"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819643/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jomfp.jomfp_85_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/31 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Context: Oral lichen planus (OLP) and oral lichenoid mucositis (OLM) are immune-mediated mucosal conditions with multifactorial etiology, with similar clinical and histological characteristics. Diagnosis should be confirmed considering both clinical and histological aspects. Some subsets are associated with immune-mediated thyroid dysfunction due to anti-thyroid peroxidase antibody (TPO) and anti-thyroglobulin antibody (TGA).
Aims: To ascertain the presence of thyroid autoantibodies in a cohort of patients with OLP and OLM from a South Indian population.
Methods and materials: This observational study comprised 21 patients with 7 cases of OLP (Group I) and 14 cases of OLM (Group II) who reported from 2021-2023 for 2 years. Serum anti-thyroid antibodies including TPO and TGA was estimated using chemiluminescence immunoassay technique along with clinical and histological aspects. Altered levels of serological parameters were compared with respect to these auto-immune conditions.
Results: Increased level of thyroid autoantibodies was observed in three (42%) of the seven cases of OLP. Two cases had elevated TPO (3-4 folds) and TGA (6-38 folds) and the subjects were above 50 years. Seven (50%) of the 14 OLM cases exhibited increased thyroid autoantibody levels and were above 50 years, predominantly females. TPO levels were increased in the range of 12 to 178 and TGA from 2 to 136 folds. Duration of these lesions were more than a year.
Conclusions: Increased thyroid autoantibodies observed in both OLP and OLM represent an underlying autoimmune response. Long-term monitoring will enable the clinicians to correlate the antibody levels with the management of these lesions.
期刊介绍：
The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.
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