Real-world experience of renal outcomes and management of PrEP users with estimated glomerular filtration rates less than 60 mL/min/1.73 m2.

Abstract

This retrospective service evaluation reviews practical measures for pre-exposure prophylaxis (PrEP) users with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² Of 35 724 PrEP users, 361 had an eGFR <60 mL/min/1.73 m², of whom 16% required non-tenofovir disoproxil/emtricitabine PrEP formulations. Majority of cases required simple and conservative management, with repeat sampling and/or stopping of the supplements and/or recreational drugs.