Dan-Lin Li, Min-Xin Liu, Ya-Jie Zheng, Yu Qin, Rong Ma, Gang Liang, Chen-Wei Pan
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引用次数: 0
Abstract
Purpose: To investigate the relationship between serum biochemical variables and corneal biomechanics in healthy young adults.
Methods: A total of 1645 healthy university students were included. Every student underwent an ophthalmologic examination by Corvis ST to measure the corneal biomechanics and a blood examination to evaluate the alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, and uric acid (UA) levels. Canonical correlation analysis (CCA) was conducted to assess their relationship.
Results: A significant relationship between serum biochemical variables and corneal biomechanics was found in both men and women. For men, the canonical correlation identified an association between the time of the first applanation (A1t), time of the second applanation (A2t), time of the highest concavity (HC-t), deflection amplitude of the highest concavity (HC-DeflA), and biomechanically corrected intraocular pressure (bIOP) with ALT, AST, urea, and UA (r = 0.235, P = 0.03). For women, a significant relationship between A1t, A2t, and bIOP with ALT and UA was found (r = 0.187, P < 0.01).
Conclusions: Elevated levels of ALT and UA were associated with softer corneas with greater elasticity and viscidity. The study provides novel evidence for the relationship between serum biochemical variables and ocular changes.
Translational relevance: These findings may help clinicians perform adequate preoperative evaluations when performing corneal surgery on patients with liver or kidney disorders, as well as helping public health practitioners understand serum biochemical variables of corneal changes in healthy people.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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