Geographic Accessibility to Clinical Trials for Head and Neck Cancers in the United States.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-05-01 Epub Date: 2025-02-14 DOI:10.1002/ohn.1168

Shiven Sharma, Dany Alkurdi, Ezdean Alkurdi, Dev Patel, Omar Alani, Keshav Sharma, Ekambir Saran, Michele M Carr

引用次数: 0

Abstract

Head and neck cancers (HNCs) are becoming more common, thereby gaining greater attention within the medical community. This retrospective trend analysis examined geographical access to HNC clinical trials in the United States from 2005 to 2024, utilizing Census data and the Haversine formula. A search of ClinicalTrials.gov identified 23,450 trial sites, with 18,394 initiated before 2020. Although linear regression revealed a slight annual increase in trial initiation (37.947 trials/year, R² = 0.014, P = .625), most observed trends did not reach statistical significance. The proportion of the population residing within 1 mile of the trials saw a minor increase (0.328%/year, R² = 0.178, P = .064). Accessibility remained consistent throughout the COVID-19 pandemic, despite a decline in trial initiation during 2020. Enhancing access to trials, especially for marginalized populations, could improve patient engagement and clinical results.

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美国头颈癌临床试验的地理可及性

头颈癌（HNCs）正变得越来越普遍，因此在医学界得到了更多的关注。这项回顾性趋势分析利用人口普查数据和哈弗辛公式，检查了2005年至2024年美国HNC临床试验的地理可及性。在ClinicalTrials.gov网站上搜索，发现了23,450个试验地点，其中18,394个是在2020年之前启动的。虽然线性回归显示试验启动量每年略有增加（37.947例/年，R²= 0.014,P = 0.625），但大多数观察到的趋势没有达到统计学意义。居住在试验1英里范围内的人口比例略有增加（0.328%/年，R²= 0.178,P = 0.064）。在2019冠状病毒病大流行期间，可获得性保持一致，尽管2020年开展的试验数量有所下降。加强试验的可及性，特别是边缘化人群的试验可提高患者参与度和临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.