Relations of hippocampal and ventricle volumes to Memory Outcomes in the Management of Myelomeningocele Study (MOMS) prenatal surgery clinical trial.

IF 2.6 3区心理学 Q3 NEUROSCIENCES

Neuropsychology Pub Date : 2025-02-01 DOI:10.1037/neu0000977

Paulina A Kulesz, Jenifer J Juranek, Jack M Fletcher, Amy J Houtrow, Larissa Bilaniuk, Sumit Pruthi, Orit A Glenn, Cora MacPherson

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引用次数: 0

Abstract

Objective: Many individuals with spina bifida myelomeningocele perform poorly on memory tasks, with hippocampal damage a possible mechanism. This study analyzed quantitative hippocampal, amygdala, and ventricular volumes to determine if prenatal surgery reduced the effects of hydrocephalus as a potential mechanism for improved memory performance in relation to hydrocephalus status.

Method: We collected magnetic resonance imaging data from 110 children enrolled in the Management of Myelomeningocele Study (n = 55 per prenatal and postnatal groups). Volumes of the hippocampus, amygdala, and lateral ventricles were quantified using FreeSurfer. Memory was assessed with the California Verbal Learning Test-Children and Children's Memory Scale.

Results: Children who received prenatal surgery did not differ from children who received postnatal surgery on memory performance. However, within the prenatal group, children who did not meet clinical criteria for hydrocephalus or had ventricular dilation but did not require shunting showed better verbal and nonverbal memory performance than those who required shunting. The magnetic resonance imaging findings indicated larger hippocampi in the prenatal group than in the postnatal group. Similarly, within the prenatal groups, children who had no hydrocephalus showed larger hippocampal volumes than children with ventricular dilation and no shunt, and these groups had larger hippocampal volumes than children with prenatal surgery and shunted hydrocephalus. There were no significant differences in amygdala volumes. Larger hippocampi were associated with better memory performance, but there was no mediating effect of ventricular volumes.

Conclusions: Prenatal surgery is associated with larger hippocampi and better memory performance in those children who did not require shunting. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

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脊髓脊膜膨出研究（mom）产前手术临床试验中海马和脑室体积与记忆结局的关系

目的：许多脊柱裂脊髓脊膜膨出患者在记忆任务中表现不佳，海马损伤可能是其机制之一。本研究分析了海马、杏仁核和脑室的定量体积，以确定产前手术是否能降低脑积水的影响，并作为脑积水状态下改善记忆表现的潜在机制。方法：我们收集了110名参加脊髓脊膜膨出管理研究的儿童的磁共振成像数据（每产前和产后组n = 55）。使用FreeSurfer对海马、杏仁核和侧脑室的体积进行量化。记忆用加州语言学习测试-儿童和儿童记忆量表进行评估。结果：接受产前手术的儿童与接受产后手术的儿童在记忆表现上没有差异。然而，在产前组中，不符合脑积水临床标准或脑室扩张但不需要分流的儿童比需要分流的儿童表现出更好的语言和非语言记忆表现。磁共振成像结果显示，产前组海马比产后组大。同样，在产前组中，没有脑积水的儿童的海马体积大于脑室扩张和没有分流的儿童，这些组的海马体积大于产前手术和分流脑积水的儿童。两组在杏仁核体积上无显著差异。更大的海马体与更好的记忆表现相关，但心室容积没有中介作用。结论：产前手术与那些不需要分流的儿童的海马较大和更好的记忆表现有关。（PsycInfo Database Record (c) 2025 APA，版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology 医学-神经科学

CiteScore

4.10

自引率

4.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.