Cytokine and Oxidative Stress Imbalances in Relation to Complex Coronary Lesions in Elderly Patients.

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Current vascular pharmacology Pub Date : 2025-02-11 DOI:10.2174/0115701611323165250211045917

Xia Li, Yongjuan Zhao, Hualan Zhou, Youdong Hu, Ying Chen, Dianxuan Guo

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引用次数: 0

Abstract

Background: Complex coronary lesions have been an understudied aspect of coronary artery disease in elderly patients. Oxidative stress and inflammation may be implicated in the pathogenesis of complex coronary lesions.

Objective: The aim of this study is to investigate the complex interplay between pro-oxidative stress response, pro-inflammatory response, and complex coronary lesions in elderly patients.

Methods: Enzyme-linked immunosorbent assays for the detection of serum biomarkers [reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), superoxide dismutase (SOD) activity, total antioxidant capacity (TAC), transforming growth factor beta (TGF-β) and interleukin-4 (IL-4)] were performed in elderly patients with complex coronary lesions.

Results: The levels of pro-oxidative stress and pro-inflammatory markers (ROS, MDA, TNF-α and IFN-γ) were increased in the complex coronary lesion group when compared with the non-complex coronary lesion group (P < 0.01) in elderly patients. Anti-oxidative stress and anti-inflammatory markers (SOD activity, TAC, TGF-β, and IL-4) were decreased in the complex coronary lesion group when compared with the non-complex coronary lesion group (P < 0.01) in elderly patients.

Conclusion: Our findings suggest that the pathogenesis of complex coronary lesions may involve pro-oxidant/anti-oxidant and pro-inflammation/anti-inflammation imbalance, as well as the interplay between oxidative stress and inflammation in elderly patients.

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细胞因子和氧化应激失衡与老年患者复杂冠状动脉病变的关系。

背景：复杂的冠状动脉病变一直是老年患者冠状动脉疾病研究不足的一个方面。氧化应激和炎症可能与复杂冠状动脉病变的发病机制有关。目的：本研究旨在探讨促氧化应激反应、促炎症反应与老年患者复杂冠状动脉病变之间的复杂相互作用。方法：采用酶联免疫吸附法检测老年复杂冠状动脉病变患者血清生物标志物[活性氧（ROS）、丙二醛（MDA）、肿瘤坏死因子-α (TNF-α)、干扰素-γ (IFN-γ)、超氧化物歧化酶（SOD）活性、总抗氧化能力（TAC）、转化生长因子-β (TGF-β)、白细胞介素-4 (IL-4)]。结果：老年患者复杂冠状动脉病变组的促氧化应激及促炎标志物ROS、MDA、TNF-α、IFN-γ水平较非复杂冠状动脉病变组升高（P < 0.01）。老年患者复杂冠状动脉病变组抗氧化应激和抗炎指标（SOD活性、TAC、TGF-β、IL-4）较非复杂冠状动脉病变组降低（P < 0.01）。结论：老年患者复杂冠状动脉病变的发病机制可能涉及促氧化/抗氧化、促炎/抗炎失衡，以及氧化应激与炎症的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).