The origin and evolution of necroptosis signaling pathway in metazoa

IF 2.7 3区农林科学 Q1 FISHERIES

Developmental and comparative immunology Pub Date : 2025-03-01 DOI:10.1016/j.dci.2025.105339

Jiejie Sun , Renle Chang , Linsheng Song

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Abstract

Necroptosis, a new form of cell death, is attracting significant attention as it is involved in the development and progression of many diseases in mammals. The structural domains and evolutionary principles of necroptotic components as well as the potential activation mechanism are not well understood in lower vertebrates and invertebrates. In the present study, TNFα, TNFR1, TLR3 and TLR4 are all presented in Mollusca and even higher phyla. ZBP1, TRADD and TRIF are only in some vertebrates. RIPK1/3 and MLKL are early originated from Mollusca and Echinodermata, respectively. Among which, RIPK1 with RHIM and Death domain and RIPK3 with a STYKc domain and two cRHIMs in Mollusca may fuse to be the classical RIPK1/3. More importantly, RIPK1/3 in Mollusca also provides structural domain conditions for the generation of the later ZBP1/TRADD/TRIF and MLKL, respectively. Taken together, necroptotic components in Mollusca are important fundamental for the evolution of necroptotic pathways. These findings provide insights into the evolutionary principles of necroptotic components and the possible activation mechanism of necroptosis pathways in various species.

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来源期刊

Developmental and comparative immunology 医学-动物学

CiteScore

6.20

自引率

6.90%

发文量

206

审稿时长

49 days

期刊介绍： Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in all areas of immunology, including comparative aspects of immunity and the evolution and development of the immune system. Manuscripts describing studies of immune systems in both vertebrates and invertebrates are welcome. All levels of immunological investigations are appropriate: organismal, cellular, biochemical and molecular genetics, extending to such fields as aging of the immune system, interaction between the immune and neuroendocrine system and intestinal immunity.