Wireless Devices for Optical Brain Stimulation: A Review of Current Developments for Optogenetic Applications in Freely Moving Mice.

IF 2.3 4区医学 Q3 BIOPHYSICS

Cellular and molecular bioengineering Pub Date : 2024-11-22 eCollection Date: 2025-02-01 DOI:10.1007/s12195-024-00832-z

Patrícia Silva, Luis Jacinto

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引用次数: 0

Abstract

Purpose: Optogenetics is an invaluable tool to study brain circuits, but typical systems rely on tethered approaches to deliver light to the brain that hinder natural behavior. With the increasing prevalence of complex behavioral phenotyping in neuroscience experiments, wireless devices for optical stimulation offer great promise to overcome these limitations.

Methods: In this work we critically review recent systems engineering and device design approaches to deliver light to the brain with wireless operation for optogenetic experiments.

Results: We describe strategies used for wireless control and communication, wireless power transfer, and light delivery to the brain with a focus on device integration for in vivo operation in freely behaving mice.

Conclusion: Recent advances in optoelectronic systems, material science, and microtechnology have enabled the design and realization of miniaturized wirelessly-controlled optical stimulators for true untethered experiments in rodent models.

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无线脑光刺激装置：光遗传学在自由运动小鼠中的应用进展综述。

目的：光遗传学是研究大脑回路的宝贵工具，但典型的系统依赖于将光传递到大脑的方法，这阻碍了自然行为。随着神经科学实验中复杂行为表型的日益普及，用于光学刺激的无线设备有望克服这些限制。方法：在这项工作中，我们批判性地回顾了最近的系统工程和设备设计方法，通过无线操作将光传递到大脑，用于光遗传学实验。结果：我们描述了用于无线控制和通信、无线电力传输和光传输到大脑的策略，重点是用于自由行为小鼠体内操作的设备集成。结论：光电系统、材料科学和微技术的最新进展使设计和实现小型化的无线控制光学刺激器成为可能，可以在啮齿动物模型上进行真正的无系绳实验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and molecular bioengineering 生物-生物物理

CiteScore

5.60

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： The field of cellular and molecular bioengineering seeks to understand, so that we may ultimately control, the mechanical, chemical, and electrical processes of the cell. A key challenge in improving human health is to understand how cellular behavior arises from molecular-level interactions. CMBE, an official journal of the Biomedical Engineering Society, publishes original research and review papers in the following seven general areas: Molecular: DNA-protein/RNA-protein interactions, protein folding and function, protein-protein and receptor-ligand interactions, lipids, polysaccharides, molecular motors, and the biophysics of macromolecules that function as therapeutics or engineered matrices, for example. Cellular: Studies of how cells sense physicochemical events surrounding and within cells, and how cells transduce these events into biological responses. Specific cell processes of interest include cell growth, differentiation, migration, signal transduction, protein secretion and transport, gene expression and regulation, and cell-matrix interactions. Mechanobiology: The mechanical properties of cells and biomolecules, cellular/molecular force generation and adhesion, the response of cells to their mechanical microenvironment, and mechanotransduction in response to various physical forces such as fluid shear stress. Nanomedicine: The engineering of nanoparticles for advanced drug delivery and molecular imaging applications, with particular focus on the interaction of such particles with living cells. Also, the application of nanostructured materials to control the behavior of cells and biomolecules.