The Role of α₁-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI:10.1007/s10517-025-06322-0

N Mansour, A L Zefirov, N I Ziyatdinova, A M Kuptsova, T L Zefirov

引用次数: 0

Abstract

We studied the influence of the α₁-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of electrical activity of the atrial myocardium from 21-day-old rats with normal sinus (preserved sinus node) or paced rhythm. Stimulation with methoxamine increased the frequency of spontaneous activity. Under the conditions of preserved sinus rhythm, the α₁-adrenergic agonist decreased the duration of the repolarization phase of the action potential, whereas at paced rhythm, this parameter increased.

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α1-肾上腺素能受体在21日龄大鼠右心房心肌细胞电活动调控中的作用。

研究α1-肾上腺素受体激动剂甲氧胺对21日龄正常（保留窦房结）和节律性心律失常大鼠心房心肌自发活动频率和电活动参数的影响。甲氧沙明刺激增加了自发活动的频率。在保持窦性心律的条件下，α1-肾上腺素能激动剂使动作电位复极期持续时间缩短，而在节律性心律下，该参数增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.

The Role of α1-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.

Abstract

The Role of α₁-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.