Bromelain and liver health: A comprehensive systematic review of preclinical studies

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-02-11 DOI:10.1016/j.clnesp.2025.02.001

Irislene Costa Pereira , Álina Mara Carvalho Pedrosa-Santos , Jorddam Almondes Martins , Athanara Alves de Sousa , Taline Alves Nobre , Lucillia Rabelo de Oliveira Torres , Felipe Cavalcanti Carneiro da Silva , Juliana Soares Severo , João Marcelo de Castro e Sousa , Francisco Leonardo Torres-Leal

{"title":"Bromelain and liver health: A comprehensive systematic review of preclinical studies","authors":"Irislene Costa Pereira , Álina Mara Carvalho Pedrosa-Santos , Jorddam Almondes Martins , Athanara Alves de Sousa , Taline Alves Nobre , Lucillia Rabelo de Oliveira Torres , Felipe Cavalcanti Carneiro da Silva , Juliana Soares Severo , João Marcelo de Castro e Sousa , Francisco Leonardo Torres-Leal","doi":"10.1016/j.clnesp.2025.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Liver diseases pose a significant challenge to the well-being of the public, given their high prevalence and the potential to escalate to liver failure and hepatocellular carcinoma. The efficacy of current therapies is rather limited, resulting in the manifestation of severe side effects. Bromelain, derived from the pineapple plant, exhibits promising prospects for the treatment of inflammatory disorders, cancer, and wound healing, although its impact on liver functionality remains largely unexplored.</div></div><div><h3>Objective</h3><div>To evaluate the efficiency of bromelain in liver injuries, we performed a systematic review of preclinical studies.</div></div><div><h3>Method</h3><div>Our search was conducted in August 2020 on PubMed and Scopus, employing the search terms “Liver disease,” “Liver injury,” and “Bromelain,” with subsequent updates in December 2023.</div></div><div><h3>Results</h3><div>Out of the 329 articles that were examined, only 7 fulfilled the criteria for inclusion.</div></div><div><h3>Conclusion</h3><div>Our research suggests that bromelain possesses both prophylactic and curative qualities in terms of liver damage, as supported by its ability to decrease enzyme levels, enhance liver structure, reduce oxidative stress markers, and regulate lipid metabolism. In summary, bromelain demonstrates a capacity to enhance liver function across a range of injury types.</div></div>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":"66 ","pages":"Pages 437-445"},"PeriodicalIF":2.9000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405457725000609","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Liver diseases pose a significant challenge to the well-being of the public, given their high prevalence and the potential to escalate to liver failure and hepatocellular carcinoma. The efficacy of current therapies is rather limited, resulting in the manifestation of severe side effects. Bromelain, derived from the pineapple plant, exhibits promising prospects for the treatment of inflammatory disorders, cancer, and wound healing, although its impact on liver functionality remains largely unexplored.

Objective

To evaluate the efficiency of bromelain in liver injuries, we performed a systematic review of preclinical studies.

Method

Our search was conducted in August 2020 on PubMed and Scopus, employing the search terms “Liver disease,” “Liver injury,” and “Bromelain,” with subsequent updates in December 2023.

Results

Out of the 329 articles that were examined, only 7 fulfilled the criteria for inclusion.

Conclusion

Our research suggests that bromelain possesses both prophylactic and curative qualities in terms of liver damage, as supported by its ability to decrease enzyme levels, enhance liver structure, reduce oxidative stress markers, and regulate lipid metabolism. In summary, bromelain demonstrates a capacity to enhance liver function across a range of injury types.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.