[Association between serum manganese level and oral cancer: a case-control study].

卫生研究 Pub Date : 2025-01-01 DOI:10.19813/j. cnki.weishengyanjiu.2025.01.016

Fengqiong Liu, Qiujiao Yang, Jing Wang, Yaping Wang, Yanfeng Weng, Ziqi Lin, Jiamin Yan, Chen Chen

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Abstract

Objective: To explore the relationship between serum manganese and risk of oral cancer.

Methods: Using a case-control study design, a total of 468 newly diagnosed oral cancer patients in the Department of Oral and Maxillofacial Surgery of the First Affiliated Hospital of Fujian Medical University, who were confirmed by surgical pathology between September 2010 and January 2020, were selected as the case group. A total of 1419 patients from the hospital's physical examination population and the community's natural population during the same period were selected as the control group. Manganese level in serum sample were detected by ICP-MS. Demographic characteristics and lifestyle factors were collected through questionnaire survey. Unconditional logistic regression was used to explore the association between serum manganese and oral cancer. Adjusted OR and corresponding 95% CI were calculated. Additionally, stratification analyses and multiplicative interaction analysis were used to explore the potential interaction of serum manganese and lifestyle factors in the association with oral cancer risk.

Results: The median and interquartile range of the level of serum manganese in case group(0.001(0.001, 4.330) μg/L) was lower than that in control group(2.381(0.001, 6.578) μg/L). After adjusting for sex, age, place of residence, family history of cancer, lifestyle and dietary habits, higher serum manganese levels were associated with a lower risk of oral cancer(OR=0.82, 95%CI 0.76-0.88)(P<0.01). Multiplicative interaction was observed between serum manganese and gender(OR=2.06, 95%CI 1.26-3.35), intake of eggs(OR=0.52, 95%CI 0.36-0.86), poultry meat(OR=1.99, 95%CI 1.21-3.28) and milk and dairy products(OR=2.40, 95%CI 1.59-3.62) in the development of oral cancer(P<0.01).

Conclusion: Serum manganese is negatively correlated with the risk of oral cancer, multiplicative interaction was observed between serum manganese and the intake of some dietary components.

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[血清锰水平与口腔癌的关系：一项病例对照研究]。

目的：探讨血清锰与口腔癌发病的关系。方法：采用病例对照研究设计，选取2010年9月至2020年1月福建医科大学第一附属医院口腔颌面外科经手术病理证实的新诊断口腔癌患者468例作为病例组。选取同期医院体检人群和社区自然人群中1419例患者作为对照组。采用ICP-MS法检测血清锰含量。通过问卷调查收集人口学特征和生活方式因素。采用无条件logistic回归探讨血清锰与口腔癌的关系。计算调整OR和相应的95% CI。此外，采用分层分析和乘法相互作用分析来探讨血清锰和生活方式因素与口腔癌风险的潜在相互作用。结果：病例组血清锰水平中位数和四分位数范围（0.001(0.001,4.330)μg/L）均低于对照组（2.381(0.001,6.578)μg/L）。在调整性别、年龄、居住地、癌症家族史、生活方式和饮食习惯等因素后，较高的血清锰水平与较低的口腔癌风险相关（OR=0.82, 95%CI 0.76-0.88）（P<0.01）。血清锰与性别（OR=2.06, 95%CI 1.26 ~ 3.35）、摄入鸡蛋（OR=0.52, 95%CI 0.36 ~ 0.86）、禽肉（OR=1.99, 95%CI 1.21 ~ 3.28）和牛奶及乳制品（OR=2.40, 95%CI 1.59 ~ 3.62）在口腔癌发生中存在乘法交互作用（P<0.01）。结论：血清锰与口腔癌发病风险呈负相关，血清锰与某些膳食成分的摄入量呈乘法相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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卫生研究

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