Psychedelics and chronic pain: self-reported outcomes on changed substance use patterns and health following naturalistic psychedelic use.

IF 1.3 Q4 CLINICAL NEUROLOGY
Nicolas G Glynos, Anne Baker, Jacob S Aday, Daniel Kruger, Kevin F Boehnke, Stephanie Lake, Philippe Lucas
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Abstract

Psychedelic substances have shown preliminary efficacy for several neuropsychiatric disorders and are currently being investigated for chronic pain conditions. However, few studies have investigated outcomes of naturalistic psychedelic use among individuals with chronic pain, and none have assessed psychedelic-related changes in substance use patterns in this population. In a cross-sectional survey of adults who reported using psychedelics to self-treat a chronic pain condition (n = 466; 46.1% women), we investigated changed substance use patterns and self-reported outcomes on physical and mental health following use of a psychedelic. Most (86.3%; n = 391/453) indicated that they ceased or decreased use of one or more non-psychedelic substances "as a result of" psychedelic use, and 21.2% (n = 83/391) indicated that the decrease in use persisted for more than 26 weeks after psychedelic use. Alcohol (71.1%; n = 226/318) and prescription opioids (64.1%; n = 100/156) had the highest proportions for ceased/decreased use. Illicit opioids (27.8%; n = 22/79) and cannabis (21.5%; n = 78/362) had the highest proportions for increased/initiated use. In multivariate regression modeling, having a motivation to reduce one's substance use was positively associated with ceasing/decreasing substance use (p < .001). Perceptions of health outcomes following psychedelic use were broadly positive, and psilocybin was reported to be the most effective substance for both physical and mental health symptoms. Although limited by a cross-sectional study design, findings from this large sample merit future investigation into the benefits and risks of naturalistic psychedelic use among individuals with chronic pain.

致幻剂和慢性疼痛:自然致幻剂使用后改变物质使用模式和健康的自我报告结果
迷幻物质已经显示出对几种神经精神疾病的初步疗效,目前正在对慢性疼痛疾病进行研究。然而,很少有研究调查慢性疼痛患者自然致幻剂使用的结果,也没有研究评估该人群中致幻剂相关物质使用模式的变化。在一项横断面调查中,报告使用致幻剂自我治疗慢性疼痛的成年人(n = 466;46.1%女性),我们调查了使用致幻剂后改变的物质使用模式和自我报告的身心健康结果。大部分(86.3%;N = 391/453)表示他们停止或减少使用一种或多种非致幻剂物质“作为”使用致幻剂的结果,21.2% (N = 83/391)表示使用致幻剂后减少使用持续超过26周。酒精(71.1%;N = 226/318)和处方阿片类药物(64.1%;N = 100/156)停止/减少使用的比例最高。非法阿片类药物(27.8%;N = 22/79)和大麻(21.5%;N = 78/362)增加/开始使用的比例最高。在多元回归模型中,有减少药物使用的动机与停止/减少药物使用呈正相关(p < 0.001)。使用致幻剂后对健康结果的看法大体上是积极的,据报道,裸盖菇素是治疗身心健康症状最有效的物质。虽然受到横断面研究设计的限制,但这个大样本的结果值得未来对慢性疼痛患者自然致幻剂使用的益处和风险进行调查。
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来源期刊
British Journal of Pain
British Journal of Pain CLINICAL NEUROLOGY-
CiteScore
3.20
自引率
11.10%
发文量
42
期刊介绍: British Journal of Pain is a peer-reviewed quarterly British journal with an international multidisciplinary Editorial Board. The journal publishes original research and reviews on all major aspects of pain and pain management. Reviews reflect the body of evidence of the topic and are suitable for a multidisciplinary readership. Where empirical evidence is lacking, the reviews reflect the generally held opinions of experts in the field. The Journal has broadened its scope and has become a forum for publishing primary research together with brief reports related to pain and pain interventions. Submissions from all over the world have been published and are welcome. Official journal of the British Pain Society.
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