Association between denture restoration for tooth loss and cognitive impairment: A systematic review and meta-analysis.

IF 3.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of prosthodontic research Pub Date : 2025-02-11 DOI:10.2186/jpr.JPR_D_24_00060

Xinyi Ma, Yichi Zhang, Jiaying Wang, Chaoming Hu, Xuejia Zhang, Xinhua Hong, Shuomin Chen, Jun Wang, Liang Chen, Yutian Wu, Qinhui Zhang, Yilin Wang, Menghan Wu, Yuge Chen, Shengbin Huang

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引用次数: 0

Abstract

Purpose: This study aimed to investigate the association between denture restoration and cognitive impairment through a meta-analysis and to assess the correlation between different degrees of tooth loss.

Study selection: Observational studies exploring the association between denture restoration and cognitive function were systematically searched across six databases from January 2000 to January 2024. Two researchers independently searched electronic databases and extracted relevant studies from all articles.

Results: This study included 24,252 participants from six observational studies. The risk ratio and 95% confidence interval (CI) were used to compare the risk of cognitive impairment. Participants who experienced tooth loss without dentures had a 1.27-fold (95% CI: 1.20-1.38) higher risk of cognitive impairment, whereas those with dentures had only a 1.01-fold (95% CI: 0.92-1.12) higher risk. In the dose-response analysis, the risk of cognitive impairment in the non-denture group increased by 1.009 times (95% CI: 1.006-1.012) for each tooth lost, whereas the denture restoration group showed a 1.003 times (95% CI: 1.000-1.006) increased risk. The years of follow-up and clinical measurement tools simultaneously explained this heterogeneity.

Conclusions: This study provides detailed evidence of a potential association between denture restoration and a reduced risk of cognitive impairment. Furthermore, there was a correlation between denture restoration and a reduced impact of the number of teeth lost on the risk of cognitive impairment. Therefore, timely and reasonable denture restoration may contribute to prevent cognitive impairment.

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来源期刊

Journal of prosthodontic research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.90

自引率

11.10%

发文量

161

期刊介绍： Journal of Prosthodontic Research is published 4 times annually, in January, April, July, and October, under supervision by the Editorial Board of Japan Prosthodontic Society, which selects all materials submitted for publication. Journal of Prosthodontic Research originated as an official journal of Japan Prosthodontic Society. It has recently developed a long-range plan to become the most prestigious Asian journal of dental research regarding all aspects of oral and occlusal rehabilitation, fixed/removable prosthodontics, oral implantology and applied oral biology and physiology. The Journal will cover all diagnostic and clinical management aspects necessary to reestablish subjective and objective harmonious oral aesthetics and function. The most-targeted topics: 1) Clinical Epidemiology and Prosthodontics 2) Fixed/Removable Prosthodontics 3) Oral Implantology 4) Prosthodontics-Related Biosciences (Regenerative Medicine, Bone Biology, Mechanobiology, Microbiology/Immunology) 5) Oral Physiology and Biomechanics (Masticating and Swallowing Function, Parafunction, e.g., bruxism) 6) Orofacial Pain and Temporomandibular Disorders (TMDs) 7) Adhesive Dentistry / Dental Materials / Aesthetic Dentistry 8) Maxillofacial Prosthodontics and Dysphagia Rehabilitation 9) Digital Dentistry Prosthodontic treatment may become necessary as a result of developmental or acquired disturbances in the orofacial region, of orofacial trauma, or of a variety of dental and oral diseases and orofacial pain conditions. Reviews, Original articles, technical procedure and case reports can be submitted. Letters to the Editor commenting on papers or any aspect of Journal of Prosthodontic Research are welcomed.