Circulating biomarkers for diagnosis and response to therapies in cancer patients.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI:10.1016/bs.ircmb.2024.08.007

Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia

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引用次数: 0

Abstract

Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for discerning cancer biomarkers, offering less invasive approaches compared to conventional methods. Utilizing increasingly robust technologies, diverse bodily fluids can unveil genetic variants, epigenetic modifications, transcriptional alterations, and metabolomic signatures associated with cancer, thereby furnishing valuable insights for clinical management. This chapter intends to review the sources of cancer-related biomarkers found in circulation, prevalent techniques utilized for their identification, and the potential implications of different biomarker types on the management of cancer. Certain biomarkers currently used in clinical practice will be addressed, as well as potential biomarkers still in the study phase, and the inherent challenges in their practical implementation.

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循环生物标志物用于癌症患者的诊断和治疗反应。

癌症是全球健康面临的重大挑战，推动全球共同努力，推进早期发现，预测治疗反应，并确定新的靶向治疗。液体活检是鉴别癌症生物标志物的有前途的途径，与传统方法相比，它提供的侵入性更小。利用日益强大的技术，不同的体液可以揭示与癌症相关的遗传变异、表观遗传修饰、转录改变和代谢组学特征，从而为临床管理提供有价值的见解。本章旨在回顾在循环中发现的癌症相关生物标志物的来源，用于鉴定它们的流行技术，以及不同生物标志物类型对癌症管理的潜在影响。将讨论目前在临床实践中使用的某些生物标志物，以及仍处于研究阶段的潜在生物标志物，以及它们在实际实施中的固有挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.