Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy: A Cross-Sectional Study.

IF 8 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC. Clinical electrophysiology Pub Date : 2025-02-04 DOI:10.1016/j.jacep.2025.01.004

Sarah Slaven, Lohit Garg, Rafay Sabzwari, Christopher Barrett, Alexis Tumolo, Lukasz Cerbin, Amneet Sandhu, Matthew Zipse, Wendy Tzou, Michael Rosenberg

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引用次数: 0

Abstract

Background: The association between premature ventricular complexes (PVCs) and ventricular function has been described in several observational studies, where it has been implied that a higher burden of PVCs plays a causative role in reducing left ventricular ejection fraction (LVEF). To date, however, few studies have examined the association of PVCs and cardiomyopathy on a population level.

Objectives: In this treatment-agnostic, cross-sectional study, we examined the association of PVC burden with depressed LVEF.

Methods: We performed an analysis of >30,000 ambulatory monitors obtained on patients from April 22, 2017, and February 20, 2023. Subjects with ≥24 hours of monitoring, a PVC burden of ≥5%, and a transthoracic echocardiogram performed within 3 months of monitoring were included. The presence of cardiomyopathy was defined as LVEF <50%. Clinical factors including comorbidities and relevant medications were included and adjusted for.

Results: The included sample included a total of 1,451 patients, with age 68.2 ± 14.5 years, female sex in 39.6%. The average PVC burden was 12.4 ± 7.4% (5%-43.4%). Of 746 subjects with a transthoracic echocardiogram, the mean LVEF was 55.6 ± 9.2% (25%-76.8%), with 171 subjects (22.9%) having an LVEF <50%. In both unadjusted and adjusted analyses, we found no significant association between percentage of PVCs and LVEF (P = 0.78), nor with PVC burden and depressed left ventricular function (P = 0.13).

Conclusions: In conclusion, we found no evidence that the PVC burden alone is an independent predictor of cardiomyopathy.

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来源期刊

JACC. Clinical electrophysiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

10.30

自引率

5.70%

发文量

250

期刊介绍： JACC: Clinical Electrophysiology is one of a family of specialist journals launched by the renowned Journal of the American College of Cardiology (JACC). It encompasses all aspects of the epidemiology, pathogenesis, diagnosis and treatment of cardiac arrhythmias. Submissions of original research and state-of-the-art reviews from cardiology, cardiovascular surgery, neurology, outcomes research, and related fields are encouraged. Experimental and preclinical work that directly relates to diagnostic or therapeutic interventions are also encouraged. In general, case reports will not be considered for publication.