{"title":"The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity.","authors":"Kaili Yang, Jun Quan, Zhi Liu, Zebing Huang, Shuyi Wang, Jia Li, Aiming Wang, Li Wu, Songman Yu, Panpan Yi, Meifang Xiao, Yayu Chen, Xingwang Hu, Shushan Zhao","doi":"10.1007/s00011-024-01967-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Recent studies have suggested that alterations in natural killer (NK) cell function may contribute to the development of COVID-19. Additionally, dysregulated NK cells may increase susceptibility to COVID-19 and affect the severity of the infection.</p><p><strong>Purpose: </strong>This study aimed to explore the causal relationship between NK cell-related immune traits and the risk of COVID-19 infection.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (MR) analysis was conducted to explore the causal relationship between NK cell-related immune traits and COVID-19. Exposure and outcome data were analyzed using the two-sample Mendelian Randomization (MR) method.</p><p><strong>Results: </strong>The results of the study suggest that there is a causal relationship between the absolute number of NK cells in COVID-19 infection and the risk of severe illness. The results also demonstrated that the morphological parameters are not causally related to COVID-19 infection but were causally related to COVID-19 hospitalization and COVID-19 severity.</p><p><strong>Conclusion: </strong>This finding has important implications for our understanding of the pathophysiology of COVID-19 and the development of future therapies and interventions for this disease.</p>","PeriodicalId":13550,"journal":{"name":"Inflammation Research","volume":"74 1","pages":"37"},"PeriodicalIF":4.8000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inflammation Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00011-024-01967-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
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Abstract
Background: Recent studies have suggested that alterations in natural killer (NK) cell function may contribute to the development of COVID-19. Additionally, dysregulated NK cells may increase susceptibility to COVID-19 and affect the severity of the infection.
Purpose: This study aimed to explore the causal relationship between NK cell-related immune traits and the risk of COVID-19 infection.
Methods: A two-sample Mendelian randomization (MR) analysis was conducted to explore the causal relationship between NK cell-related immune traits and COVID-19. Exposure and outcome data were analyzed using the two-sample Mendelian Randomization (MR) method.
Results: The results of the study suggest that there is a causal relationship between the absolute number of NK cells in COVID-19 infection and the risk of severe illness. The results also demonstrated that the morphological parameters are not causally related to COVID-19 infection but were causally related to COVID-19 hospitalization and COVID-19 severity.
Conclusion: This finding has important implications for our understanding of the pathophysiology of COVID-19 and the development of future therapies and interventions for this disease.
期刊介绍：
Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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