Withanolide glycosides from Physalis volubilis

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-10 DOI:10.1016/j.fitote.2025.106428

Ana-L. Pérez-Castorena , Tonantzin G. Anguheven L. , M. Azucena Martínez R. , Jesús Morales-Jiménez , Emma Maldonado , Mahinda Martínez

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引用次数: 0

Abstract

The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1–3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations. Nine of the obtained compounds (2, 3, 6, 7, 10, 11, and 13–15) were evaluated for their qualitative antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Compound 2 showed the highest inhibition of bacterial growth. Its minimum inhibitory concentrations against S. aureus ATCC® 25923™ and a clinical isolate of Methicillin-resistant S. aureus (MRSA) were 62.5 and 125 μg/mL, respectively.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.