Metabolic byproduct utilization and the evolution of mutually beneficial cooperation in Escherichia coli.

IF 3.1 2区 环境科学与生态学 Q2 ECOLOGY
Evolution Pub Date : 2025-02-13 DOI:10.1093/evolut/qpaf026
Nan Ye, Beibei Hou, Jianxiao Song, Derek W Dunn, Zhanshan Sam Ma, Rui-Wu Wang
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引用次数: 0

Abstract

Understanding how cooperation evolves in microbial populations, particularly under environmental stress such as antibiotic exposure, remains a key topic in evolutionary biology. Here, we investigate cooperative interactions between antibiotic-resistant and antibiotic-sensitive strains of Escherichia coli. Under antibiotic stress, a small number of antibiotic-sensitive strains rapidly evolve into antibiotic-resistant strains. Resistant E. coli produce indole, which induces a protective response in sensitive cells, enabling them to survive in antibiotic stress conditions. In turn, antibiotic-sensitive E. coli could help reduce toxic accumulation of indole, indirectly benefiting the resistant strain. Indole is harmful to the growth of the antibiotic-resistant strain but benefits the antibiotic-sensitive strain by helping turn-on the multi-drug exporter to neutralize the antibiotic. This mutual exchange leads to increased fitness for both strains in cocultures, demonstrating a mechanism by which mutually beneficial cooperation can evolve in bacterial communities. Our findings provide insight into how mutualism can emerge under antibiotic pressure through metabolic byproduct exchange, revealing new dynamics in the evolution of bacterial cooperation.

大肠杆菌代谢副产物利用与互利合作的进化。
了解微生物群体的合作是如何进化的,特别是在抗生素暴露等环境压力下,仍然是进化生物学的一个关键话题。在这里,我们研究抗生素耐药菌株和抗生素敏感菌株之间的合作相互作用。在抗生素胁迫下,少数对抗生素敏感的菌株迅速进化为耐药菌株。耐药大肠杆菌产生吲哚,在敏感细胞中引起保护反应,使它们能够在抗生素压力条件下生存。反过来,对抗生素敏感的大肠杆菌可以帮助减少吲哚的毒性积累,间接有利于耐药菌株。吲哚对抗生素耐药菌株的生长有害,但对抗生素敏感的菌株有益,因为它有助于开启多种药物出口来中和抗生素。这种相互交换导致共培养中两种菌株的适应性增加,证明了细菌群落中互利合作可以进化的机制。我们的研究结果揭示了在抗生素压力下,细菌如何通过代谢副产物交换产生共生关系,揭示了细菌合作进化的新动态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Evolution
Evolution 环境科学-进化生物学
CiteScore
5.00
自引率
9.10%
发文量
0
审稿时长
3-6 weeks
期刊介绍: Evolution, published for the Society for the Study of Evolution, is the premier publication devoted to the study of organic evolution and the integration of the various fields of science concerned with evolution. The journal presents significant and original results that extend our understanding of evolutionary phenomena and processes.
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