A Comprehensive Review on Anticancer Potential of Pulicaria Plants and their Derivatives.

IF 2.3 4区医学 Q3 ONCOLOGY

Current cancer drug targets Pub Date : 2025-02-12 DOI:10.2174/0115680096358261250115114608

Tahere Barabadi, Hossein Rahimi, Seyed Mahdi Mohamadi-Zarch, Seyyed Majid Bagheri

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引用次数: 0

Abstract

The genus Pulicaria, belonging to the Asteraceae family, includes 100 species distributed from Europe to North Africa and Asia, especially around the Mediterranean. A number of extracts and compounds of this genus have been found to have anticancer effects on various cancer cell lines. Google, PubMed, Web of Science and Scopus databases were searched for articles related to Pulicaria or its isolated compounds. The search was conduct-ed using various keywords, including "Pulicaria and anticancer activity". After the review, the relevant articles were summarized and included in the review article. Fortunately, the re-sults of this review showed that relatively comprehensive studies have been conducted in this field, and the presence of various compounds in these plants can be used in cancer re-search. The results of our review showed that Pulicaria vulgaris has the strongest effect and Pulicaria dysenterica has the weakest effect on cancer cells. Future studies should focus on finding purer compounds and investigating the anticancer effects of these compounds. These herbal compounds can also be used alongside standard drugs to treat cancer, especially to reduce the effect of drug resistance.

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茯苓属植物及其衍生物抗癌潜力综述。

石菖蒲属，属于菊科，有100种，分布于欧洲到北非和亚洲，特别是地中海周围。该属植物的许多提取物和化合物已被发现对各种癌细胞系具有抗癌作用。在b谷歌、PubMed、Web of Science和Scopus等数据库中检索了与黄菖蒲及其分离化合物相关的文章。搜索使用了各种关键词，包括“白头翁和抗癌活性”。综述结束后，对相关文章进行总结，纳入综述文章。幸运的是，这篇综述的结果表明，在这一领域已经进行了比较全面的研究，这些植物中存在的各种化合物可以用于癌症研究。结果表明，对肿瘤细胞的杀伤作用以寻常皮草最强，而痢疾皮草最弱。未来的研究应集中在寻找更纯净的化合物和研究这些化合物的抗癌作用。这些草药化合物也可以与标准药物一起用于治疗癌症，特别是减少耐药性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.