Melanoma in older adolescents and young adults patients: a population-based analysis of the Surveillance, Epidemiology, and End Results Program database from 2000-2019.

Abstract

Epidemiologic characteristics of melanoma in older adolescents and young adults (AYAs) patients aged 15 to 39 years are unknown. We examined the epidemiologic characteristics of melanoma in AYA patients and then extracted demographic and pathologic data for this retrospective cohort study from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019). Cox regression analyses were used to assess the risk of all-cause death, cancer-specific death, and second primary malignancy. A total of 2,835 AYA patients with melanoma were included, of whom 926 (32.66%) had a second primary malignancy. The incidence of melanoma in AYAs patients decreased from 0.9 per 1,000,000 person-year in 2000 to 0.2 per 1,000,000 person-year in 2019, with the average annual percentage change (AAPC) of -6.3% (95% CI: -7.2% to -5.3%). Melanoma patients who were pigmented (hazard ratio (HR)=3.794; 95%CI: 1.382-10.412) were associated with an increased a risk of second primary malignancies, whereas patients with Breslow depth of >4 mm (HR=0.517; 95%CI: 0.379-0.706), melanoma site in the trunk (HR=0.700; 95%CI: 0.536-0.915), and extremities (HR=0.760; 95%CI: 0.585-0.988) were associated with a decreased risk of second primary malignancies. This study may provide statistical data on the epidemiologic characteristics of melanoma in patients with AYAs.