{"title":"Specific Features of the Chromosomal Composition of the Micronuclei in Women Living under Chronic Radiation Exposure.","authors":"Yu R Akhmadullina","doi":"10.1007/s10517-025-06337-7","DOIUrl":null,"url":null,"abstract":"<p><p>Chromosomal composition of micronuclei of phytohemagglutinin-stimulated peripheral blood T lymphocytes in women chronically exposed to radiation due to their residence in the Techa riverside settlements in the Sothern Urals (mean age 76.4±1.2 years, mean cumulative dose for the red bone marrow 1.4±0.3 Gy) was analyzed using the cytochalasin-block micronucleus assay and multicolor fluorescent in situ hybridization (mFISH). Exposed women demonstrated an increase in the number of chromosomes eliminated from cell nucleus, but the frequency of micronuclei did not differ from that in the comparison group. High variability of the frequency of micronuclei was also noted in the group of exposed women. In all the women, X-chromosome and autosomes 2, 16 were significantly more often eliminated than other chromosomes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"363-366"},"PeriodicalIF":0.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06337-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/13 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Chromosomal composition of micronuclei of phytohemagglutinin-stimulated peripheral blood T lymphocytes in women chronically exposed to radiation due to their residence in the Techa riverside settlements in the Sothern Urals (mean age 76.4±1.2 years, mean cumulative dose for the red bone marrow 1.4±0.3 Gy) was analyzed using the cytochalasin-block micronucleus assay and multicolor fluorescent in situ hybridization (mFISH). Exposed women demonstrated an increase in the number of chromosomes eliminated from cell nucleus, but the frequency of micronuclei did not differ from that in the comparison group. High variability of the frequency of micronuclei was also noted in the group of exposed women. In all the women, X-chromosome and autosomes 2, 16 were significantly more often eliminated than other chromosomes.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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