Are Neurocognitive Deficits Associated With Gastrointestinal Symptoms in Children due to COVID-19?

IF 1.6 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-02-13 DOI:10.1002/jdn.70007

Kalliopi Megari, Evanthia Thomaidou, Maria Eleni Palioura, Stelios Parasxiakos, Aglaia Skoutara, Panagiota Stougioude, Maria Theodoratou, Maria Sofologi, Efthymia Efthymiou, Soultana Papadopoulou, Dimitra V. Katsarou

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Abstract

Background and Objectives

Children with gastrointestinal symptoms due to COVID-19 may experience neurocognitive deficits. Symptoms include difficulty in concentration, memory and other cognitive functions. The deficits could be caused by the virus itself or due to the physical and psychological stress of the pandemic.

Materials and Methods

In this study, we examined 65 children, 32 children with gastrointestinal symptoms, and we compared them to 33 children without gastrointestinal symptoms due to COVID-19, to investigate whether gastrointestinal symptoms affected neurocognitive status in children with COVID-19.

Results

We found that there was a significant relationship between cognitive function and GI symptoms, as well as between cognitive function and the severity of these symptoms. This indicates that COVID-19 patients with GI symptoms may be at risk for developing problems with their memory and other aspects of cognition.

Conclusions

Early detection and intervention may help young children recover faster and return to their typical cognitive functioning.

Abstract Image

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COVID-19引起的儿童神经认知缺陷与胃肠道症状相关吗？

背景和目的COVID-19引起胃肠道症状的儿童可能会出现神经认知障碍。症状包括注意力、记忆力和其他认知功能的困难。这种缺陷可能是由病毒本身造成的，也可能是由于大流行造成的身体和心理压力造成的。材料与方法本研究纳入65例儿童，其中32例有胃肠道症状，并与33例无胃肠道症状的新冠肺炎患儿进行比较，探讨胃肠道症状是否影响新冠肺炎患儿的神经认知状态。结果我们发现认知功能与胃肠道症状之间，以及认知功能与这些症状的严重程度之间存在显著的关系。这表明，出现胃肠道症状的COVID-19患者可能有出现记忆和其他认知方面问题的风险。结论早期发现和干预可使幼儿更快康复，恢复正常的认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.