Probing Depth Reduction Following Peri-Implantitis Treatment: A Systematic Review and Component Network Meta-Analysis

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2025-02-13 DOI:10.1111/cid.70010

Yun-Chen Liu, Yih-Yun Sun, Anna Simonelli, Roberto Farina, Leonardo Trombelli, Chen-Ying Wang, Yu-Kang Tu

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引用次数: 0

Abstract

Objective

In this update of a previous systematic review, we compared the effects of surgical and non-surgical treatments for peri-implantitis through the component network meta-analysis (CNMA) with probing depth (PD) reduction as the outcome.

Materials and Methods

Literature search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Embase databases from August 2010 to June 2023. Randomized controlled trials (RCTs), comparing non-surgical or surgical treatments for peri-implantitis with 6–12 months of follow-up and reported changes in PD, were included. Treatment effects were assessed using a CNMA model based on additivity assumption. We calculated the intraclass correlation coefficient (ICC) to adjust the standard errors for multiple implants within the same patient.

Results

Our systematic review identified 44 RCTs, which included 46 treatment regimens consisting of 15 components. These RCTs formed a disconnected network consisting of 11 subnetworks. Surgical treatments with bone grafts and membranes generally attained greater PD reduction than non-surgical treatments, although bone grafts and membranes as components provided moderate benefits. The effect size of antibiotics is greater in non-surgical than surgical treatments, while there is considerable uncertainty regarding the effect size of implantoplasty. Additionally, the effectiveness of components varied between surgical and non-surgical treatments.

Conclusion

Current evidence does not yield sufficiently robust estimates for identifying optimal surgical and non-surgical treatment regimens for peri-implantitis, so the findings of our study should be interpreted cautiously. A coordinated strategy is required for designing future trials to fill the gaps in our current knowledge and develop more reliable recommendations.

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种植体周围炎治疗后探查深度减少：系统回顾和成分网络荟萃分析

目的在更新之前的系统综述中，我们通过成分网络meta分析（CNMA）比较了手术和非手术治疗种植体周围炎的效果，并以探探深度（PD）减少为结果。资料与方法2010年8月至2023年6月在PubMed、Cochrane Central Register of Controlled Trials和Embase数据库中进行文献检索。包括随机对照试验（RCTs），比较非手术或手术治疗种植体周围炎6-12个月的随访和报告的PD变化。采用基于可加性假设的CNMA模型评估处理效果。我们计算了类内相关系数（ICC）来调整同一患者内多个种植体的标准误差。我们的系统评价纳入了44项随机对照试验，包括15个组成部分的46个治疗方案。这些rct形成了一个由11个子网组成的断开网络。骨移植和骨膜的手术治疗通常比非手术治疗获得更大的PD减少，尽管骨移植和骨膜作为组件提供适度的益处。抗生素在非手术治疗中的效果比手术治疗的效果大，而种植成形术的效果有相当大的不确定性。此外，各成分的有效性在手术和非手术治疗之间有所不同。结论：目前的证据还不能为确定最佳的手术和非手术治疗方案提供足够可靠的估计，因此我们的研究结果应谨慎解读。需要一个协调的策略来设计未来的试验，以填补我们目前知识的空白，并提出更可靠的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.