Cover Feature: Overexpression of the Global Transcriptional Regulator LaeA Leads to Production of Cyclic Lipopeptides in Marine-Derived Aspergillus niger L14 (Chem. Biodiversity 2/2025)

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-02-14 DOI:10.1002/cbdv.202570202

Wenjuan Zhou, Mengshi Li, Wei Wang, Xuelian Bai, Huawei Zhang

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Abstract

Cover Feature. Global transcriptional regulators of microorganisms play a key role in gene expression responsible for biosynthesis of various secondary metabolites. In article number e202402704, Huawei Zhang, Xuelian Bai, and co-workers report overexpression of the global transcriptional regulator LaeA in a marine sponge-derived fungus Aspergillus niger L14 led to the isolation of previously undiscovered bioactive cyclolipopeptides in the wild-type strain. Gene expression of polyketide synthase-nonribosomal peptide synthetase (PKS/NRPS) hybrids and amino acid metabolism had been greatly enhanced in the mutant L14-OE::LaeA2, demonstrating overexpression of LaeA is an effective approach to awaken cryptic biosynthetic gene clusters (BGCs) for production of cyclolipopeptides.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.