Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products

IF 1.8 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Rapid Communications in Mass Spectrometry Pub Date : 2025-02-14 DOI:10.1002/rcm.10009

Ling Yan, Wenjun Zheng, Zian Lin

{"title":"Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products","authors":"Ling Yan, Wenjun Zheng, Zian Lin","doi":"10.1002/rcm.10009","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Rational</h3>\n \n <p>Benzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine-disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB-DMTP-covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method for the quantitative analysis of 2,4-dihydroxybenzophenone (BP-1) in PCPs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The TAPB-DMTP-COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI-MS substrate. The performance of TAPB-DMTP-COF nanofilm-assisted LDI-MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (α-cyano-4-hydroxycinnamic acid [CHCA], 2,5-dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP-1 in PCPs.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The TAPB-DMTP-COF nanofilm-assisted LDI-MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP-1 in PCPs was quantified with excellent linearity (1–20 μg/mL, <i>r</i> = 0.9993), a low detection limit (0.3 μg/mL), and recovery rates of 94.2%–104.4%, demonstrating the potential of TAPB-DMTP-COF nanofilm for sensitive and reliable small-molecule analysis.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>TAPB-DMTP-COF nanofilm-assisted LDI-MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP-1 in PCPs, highlighting its suitability for analyzing complex samples.</p>\n </section>\n </div>","PeriodicalId":225,"journal":{"name":"Rapid Communications in Mass Spectrometry","volume":"39 10","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rapid Communications in Mass Spectrometry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/rcm.10009","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

Rational

Benzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine-disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB-DMTP-covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method for the quantitative analysis of 2,4-dihydroxybenzophenone (BP-1) in PCPs.

Methods

The TAPB-DMTP-COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI-MS substrate. The performance of TAPB-DMTP-COF nanofilm-assisted LDI-MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (α-cyano-4-hydroxycinnamic acid [CHCA], 2,5-dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP-1 in PCPs.

Results

The TAPB-DMTP-COF nanofilm-assisted LDI-MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP-1 in PCPs was quantified with excellent linearity (1–20 μg/mL, r = 0.9993), a low detection limit (0.3 μg/mL), and recovery rates of 94.2%–104.4%, demonstrating the potential of TAPB-DMTP-COF nanofilm for sensitive and reliable small-molecule analysis.

Conclusion

TAPB-DMTP-COF nanofilm-assisted LDI-MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP-1 in PCPs, highlighting its suitability for analyzing complex samples.

查看原文本刊更多论文

共价有机框架纳米膜辅助激光解吸电离质谱法测定个人护理用品中二苯甲酮衍生物

理性二苯甲酮衍生物，通常用作个人护理产品（pcp）中的紫外线过滤器，由于其内分泌干扰作用而广泛流行并引起关注。对它们的检测需要灵敏、高效的分析方法。在这项研究中，我们建立了tapb - dmtp -共价有机框架（COF）纳米膜辅助激光解吸电离质谱（LDI-MS）方法，用于定量分析pcp中2,4-二羟基二苯甲酮（BP-1）。方法在氧化铟锡（ITO）玻璃上合成ttap - dmtp - cof纳米膜，并将其作为LDI-MS衬底。将TAPB-DMTP-COF纳米膜辅助LDI-MS用于分析小分子（如二苯甲酮衍生物、邻苯二甲酸酯、氨基酸、糖和核苷）的性能与常规有机基质（α-氰基-4-羟基肉桂酸[CHCA]、2,5-二羟基苯甲酸[DHB]和辛子酸[SA]）进行比较。进一步评价了该方法的重现性、耐盐性、灵敏度和稳定性。最后，应用该技术定量pcp中的BP-1。结果与CHCA、DHB和SA相比，ttap - dmtp - cof纳米膜辅助LDI-MS具有更强的质谱信号和更清晰的小分子背景。该方法重现性好（RSD = 6.10%），稳定性可达30天。BP-1在pcp中的定量具有良好的线性（1 ~ 20 μg/mL, r = 0.9993），低检出限（0.3 μg/mL），回收率为94.2% ~ 104.4%，显示了TAPB-DMTP-COF纳米膜用于灵敏、可靠的小分子分析的潜力。结论ttap - dmtp - cof纳米膜辅助LDI-MS检测小分子，包括二苯甲酮衍生物，具有分析快速、背景干净、重复性好等优点。该方法成功地定量了pcp中的BP-1，突出了其分析复杂样品的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.