Suspicion and referral of patients with transthyretin amyloid cardiomyopathy: Recommendations by a Portuguese multidisciplinary expert panel

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia Pub Date : 2025-02-01 DOI:10.1016/j.repc.2024.12.002

Dulce Brito , João Agostinho , Carlos Aguiar , Sílvia Aguiar Rosa , Nuno Cardim , Cândida Fonseca , Nuno Marques , Pedro Moraes Sarmento , Patrícia Rodrigues , Jonathan Santos , Maria João Vidigal Ferreira , Olga Azevedo

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引用次数: 0

Abstract

Early diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) is crucial for better disease management and outcome. To ensure timely diagnosis, a multidisciplinary panel of Portuguese experts, including cardiologists, internal medicine specialists, and general practitioners, have developed a national consensus to aid physicians in enhancing the referral of patients with suspicion of ATTR-CM in Portugal.

A structured approach was used to develop the consensus: (1) an online survey aimed at identifying clinical red flags, patient journeys, and diagnostic tools related to ATTR-CM; (2) a face-to-face roundtable meeting where the survey findings were discussed and a consensus was reached on referral and diagnostic algorithms for ATTR-CM in Portugal; and (3) critical review of the proposed algorithms.

The referral and diagnostic algorithms for ATTR-CM in Portugal were developed considering current recommendations, but also the existence of a nationwide network of specialized cardiomyopathy clinics and national reference centers for familial amyloid polyneuropathy due to the endemic p.V50M variant.

This collaborative effort aims to enhance awareness, facilitate timely referrals and improve early diagnosis, ultimately ensuring better management of ATTR-CM patients in Portugal.

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转甲状腺蛋白淀粉样心肌病患者的怀疑和转诊：葡萄牙多学科专家小组的建议

甲状腺素转淀粉样心肌病（atr - cm）的早期诊断对于更好的疾病管理和预后至关重要。为了确保及时诊断，一个由葡萄牙专家组成的多学科小组，包括心脏病专家、内科专家和全科医生，已经形成了一种全国共识，以帮助医生加强对葡萄牙疑似atr - cm患者的转诊。采用结构化方法来达成共识：(1)在线调查，旨在识别与atr - cm相关的临床危险信号、患者旅程和诊断工具；(2)面对面圆桌会议，讨论调查结果，并就葡萄牙atr - cm的转诊和诊断算法达成共识；(3)对所提出算法的批判性回顾。葡萄牙atr - cm的转诊和诊断算法的制定考虑了当前的建议，同时也考虑了全国性的专业心肌病诊所网络和全国性的家族性淀粉样蛋白多发性神经病变参考中心的存在。这一合作努力旨在提高认识，促进及时转诊和改善早期诊断，最终确保更好地管理葡萄牙的atr - cm患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Portuguesa De Cardiologia CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.70

自引率

22.20%

发文量

205

审稿时长

54 days

期刊介绍： The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in 1982 with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention. The Journal is a monthly publication with high standards of quality in terms of scientific content and production. Since 1999 it has been published in English as well as Portuguese, which has widened its readership abroad. It is distributed to all members of the Portuguese Societies of Cardiology, Internal Medicine, Pneumology and Cardiothoracic Surgery, as well as to leading non-Portuguese cardiologists and to virtually all cardiology societies worldwide. It has been referred in Medline since 1987.