Novel monoterpene indole alkaloids from the fruits of Bousigonia mekongensis and their antiproliferative effects on HepG2 cells

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-11 DOI:10.1016/j.fitote.2025.106430

De-Dong Zhou , Yuan-Yuan Bai , Yuan-Yi Lin , Xiao-Dong Zhao , Zhi-Yuan Lu , Zhi-Wei Wang , Xiao-Jing Wang

引用次数: 0

Abstract

Three new monoterpene indole alkaloids (1–3) together with eight known alkaloids (4–11) were isolated from the fruits of Bousigonia mekongensis. Compounds 1 and 2 were the first examples of akuammicine-Aspidosperma type bisindole alkaloids. Their structures were elucidated by NNR spectra, MS data and electronic circular dichroism (ECD) spectra. All compounds were evaluated for their cytotoxic activity against HepG2 liver cancer cells in vitro. Compounds 1, 4, 9 and 11 showed antiproliferative activity with IC₅₀ values of 15.74 ± 1.37, 8.55 ± 0.97, 9.23 ± 1.11, and 0.80 ± 0.44 μM, respectively (0.51 ± 0.14 μM for the control, doxorubicin).

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.