Human amniotic mesenchymal stem cells improve patency and regeneration of electrospun biodegradable vascular grafts via anti-thrombogenicity and M2 macrophage polarization

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-02-09 DOI:10.1016/j.colsurfb.2025.114559

Nuoxin Wang , Haoyuan Wang , Dong Weng , Bin Wang , Juan Wang , Jing He , Xiumei Mo , Feng Wang , Zhixu He

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引用次数: 0

Abstract

Small-diameter vascular grafts (SDVGs) are prone to thrombosis and have low long-term patency rates for various reasons, which cannot meet the clinical requirements. In this work, Human amniotic mesenchymal stem cell (hAMSC) seeding electrospun polylactic acid-co-polycaprolactone (PLCL) SDVGs are fabricated and their application potential is systematically evaluated. The SDVG has excellent mechanical properties. PLCL eletrospinning membrane has no cytotoxicity. The SDVG has a porous fibrous tube wall, uniform distribution of hAMSCs, and good cell compatibility, blood compatibility, histocompatibility and mechanical properties. hAMSCs loading can improve the acute antithrombotic ability, patency and in vivo regeneration effect of PLCL electrospun SDVGs. The mechanism is related to hAMSCs increasing the content of endothelial cells, contractile smooth muscle cells, and M2 macrophages, as well as activating extracellular matrix production.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.