Lethal Case of Microbacterium paraoxydans Bloodstream Infection Associated with Mitral Endocarditis in Human: A Case Report, analyses of the 16S rDNA sequences and review of the literature

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-02-08 DOI:10.1016/j.diagmicrobio.2025.116739

Pierre Serandour , Chloé Plouzeau , Anthony Michaud , Lauranne Broutin , Julie Cremniter , Christophe Burucoa , Maxime Pichon

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Abstract

Introduction

Microbacterium species are gram-positive, non-fermentative, yellow-pigmented rods commonly found in animals and various environmental sources. Herein is reported the first case of a fatal bloodstream infection associated with mitral endocarditis caused by Microbacterium paraoxydans in a human patient.

Methods

A 64-year-old man without significant infectious risk factors, except for rheumatoid spondylarthritis treatment, developed severe chest pain, paralysis of the left leg, respiratory distress, and high fever. Diagnostic investigations revealed ischemic stroke and mitral insufficiency. Despite valve replacement surgery and antibiotic treatment, the patient's condition deteriorated, resulting in valve disinsertion, pneumopathy, and death.

Results

Blood cultures taken later confirmed the presence of Microbacterium sp., identified as M. paraoxydans by 16S rDNA gene sequencing.

Conclusion

This case highlights the importance of using sequencing for accurate identification of Microbacterium species. This report emphasizes the need for research and surveillance to understand the clinical characteristics, treatment strategies, and impact of Microbacterium infections in humans.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.