Clinical Efficacy of Ganglioside Combined with Methylprednisolone in the Treatment of Spinal Cord Injury and Its Effect on Inflammatory Response and Oxidative Stress Factors.

Dongliang Ren, Hui Li, Xiangdong Liu, Meihua Wang
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Abstract

Objective: To determine the clinical efficacy of monosialotetrahexosylganglioside (GM1) combined with methylprednisolone in the treatment of spinal cord injury (SCI).

Study design: An observational study. Place and Duration of the Study: Department of Orthopaedics, Baoding No.1 Central Hospital, Baoding, Hebei, China, from January 2018 to June 2021.

Methodology: A total of 80 patients with SCI were divided into control and observation groups according to treatment methods, the control group receiving methylprednisolone treatment and the observation group receiving methylprednisolone combined with GM1. The effective rate of treatment, time of normal muscle strength recovery, walk on the ground, and hospital stay were compared. The changes in the American Spinal Injury Association (ASIA) score, activity of daily living (ADL), serum inflammatory factors, oxidative stress factor levels, and adverse reactions were recorded.

Results: The effective rate of clinical efficacy of the observation group was 92.50%, surpassing the control group's which was 75.00% (χ2 = 4.501, p = 0.034). The observation group had a shorter recovery time for muscle strength, walking time, and hospital stay compared to the control group (p <0.05). After treatment, the ADL scores of both groups were higher than before treatment, and the degree of increase in the observation group was higher than the control group (p <0.05). The levels of serum tumour necrosis factor-α (TNF-α) and interleukin-8 (IL-8) for all patients were significantly reduced, with the observation group showing a more significant decrease (p <0.05). There was a notable increase in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels in both groups, while the levels of malondialdehyde (MDA) decreased significantly. GSH-Px, SOD, and MDA levels were significantly greater in the observation group (p <0.05).

Conclusion: The combination of methylprednisolone and MG1 treatment of SCI can significantly reduce the inflammatory response and improve clinical efficacy.

Key words: Spinal cord injury, Ganglioside, Methylprednisolone, Inflammatory indicators, Oxidative stress.

神经节苷脂联合甲基强的松龙治疗脊髓损伤的临床疗效及对炎症反应和氧化应激因子的影响。
目的:探讨单唾液酸四己糖神经节苷脂(GM1)联合甲基强的松龙治疗脊髓损伤(SCI)的临床疗效。研究设计:观察性研究。研究地点和时间:中国河北省保定市保定市第一中心医院骨科,2018年1月至2021年6月。方法:80例脊髓损伤患者按治疗方法分为对照组和观察组,对照组采用甲泼尼龙治疗,观察组采用甲泼尼龙联合GM1治疗。比较治疗有效率、正常肌力恢复时间、地面行走时间和住院时间。记录美国脊髓损伤协会(ASIA)评分、日常生活活动(ADL)、血清炎症因子、氧化应激因子水平及不良反应的变化。结果:观察组临床有效率为92.50%,优于对照组的75.00% (χ2 = 4.501, p = 0.034)。观察组患者肌力恢复时间、步行时间、住院时间均较对照组短(p)。结论:甲泼尼龙联合MG1治疗脊髓损伤可显著降低炎症反应,提高临床疗效。关键词:脊髓损伤,神经节苷脂,甲基强的松龙,炎症指标,氧化应激
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