Active search for tuberculosis in three youth detention centers in Peru.

Q3 Medicine
Judith Jimenez, Ana Karina Millones, Daniela Puma, Jesús Peinado, Blanca Martínez, Marco Tovar, Leonid Lecca
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Abstract

Motivation for the study. With tuberculosis being the leading cause of death due to infectious diseases in the world, and having a detection gap of 20-40%, there is a need to implement active search strategies for the disease in different vulnerable populations such as juvenile correctional facilities. Main findings. We found a screening rate by active search of 1250 per 100,000 screened, being 10 times more than the rate in the general population. Seventy-five percent of GeneXpert-positive cases were asymptomatic. Implications. By using innovative TB screening mechanisms and algorithms, cases can be identified early, which favors treatment prognosis, as well as reducing the chain of disease transmission. This study aimed to describe the rate of tuberculosis (TB) found by using the active search strategy in teenagers and youths in three youth detention centers. TB was screened through the active search algorithm with chest X-ray, the automated reading was carried out by artificial intelligence software, the GeneXpert Ultra MTB/RIF molecular test, and clinical evaluation. A total of 640 individuals were screened, 94 (14.6%) had an abnormal chest X-ray. Of those screened, we obtained 105 GeneXpert tests of which 94 had abnormal X-rays, 9 were respiratory symptomatic and 2 were on antiretroviral treatment with TB clinical picture. We obtained 8 (8.5%) cases of TB detected with GeneXpert, 7 with abnormal radiography and 1 with normal radiography. Finally, of these 8 cases, 3 were cases of rifampicin-resistant tuberculosis (RR-TB) (42.8%). The rate of screening by active search was 1250 per 100,000 screened, 10 times higher than the rate in the general population. We recommend the inclusion of youth detention centers as target groups for systematic screening and the development of interventions to reduce the risk of TB infection.

在秘鲁的三个青少年拘留中心积极寻找肺结核。
学习的动机。由于结核病是世界上因传染病导致死亡的主要原因,并且存在20-40%的发现差距,因此有必要在不同的弱势人群(如少年教养设施)中实施积极的疾病搜索战略。主要发现。我们发现主动搜索的筛查率为每10万人中有1250人,是普通人群的10倍。75%的genexpert阳性病例无症状。的影响。通过使用创新的结核病筛查机制和算法,可以及早发现病例,这有利于治疗预后,并减少疾病传播链。本研究旨在描述使用主动搜索策略在三个青少年拘留中心的青少年中发现的结核病(TB)率。通过胸片主动搜索算法筛选TB,人工智能软件自动读取,GeneXpert Ultra MTB/RIF分子检测,临床评估。共筛查了640人,其中94人(14.6%)胸部x线异常。在筛选的患者中,我们获得了105份GeneXpert测试,其中94份有异常x射线,9份有呼吸道症状,2份接受抗逆转录病毒治疗并伴有结核病临床表现。GeneXpert检测结核8例(8.5%),x线摄影异常7例,正常1例。最后,8例病例中,3例为利福平耐药结核(RR-TB),占42.8%。主动搜索的筛查率为1250 / 10万,比一般人群的筛查率高10倍。我们建议将青少年拘留中心作为目标群体纳入系统筛查和制定干预措施,以降低结核病感染的风险。
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来源期刊
Revista Peruana de Medicina de Experimental y Salud Publica
Revista Peruana de Medicina de Experimental y Salud Publica Medicine-Public Health, Environmental and Occupational Health
CiteScore
3.00
自引率
0.00%
发文量
57
审稿时长
12 weeks
期刊介绍: La Revista Peruana de Medicina Experimental y Salud Pública (RPMESP) es el órgano oficial de difusión científica del Instituto Nacional de Salud (INS) del Perú. Es una publicación arbitrada por pares, de periodicidad trimestral, de ámbito y difusión mundial, indizada en MEDLINE/Index Medicos, SCOPUS, EMBASE, SciELO Salud Pública y otras bases de datos internacionales. La RPMESP es distribuida en su versión impresa y electrónica, con acceso gratuito a texto completo. La RPMESP publica artículos referidos a temas del ámbito biomédico y de salud pública, resaltando aportes prácticos, que contribuyan a mejorar la situación de salud del país y de la región. Propicia el intercambio de la experiencia científica en salud entre instituciones y personas dedicadas a la investigación dentro y fuera del Perú a fin de promover el avance y la aplicación de la investigación en salud.
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