Presumed Mitomycin C-Induced Retinal Toxicity Following Combined Cataract and Xen Gel Stent Surgery.

Q3 Medicine

Retinal Cases and Brief Reports Pub Date : 2025-02-05 DOI:10.1097/ICB.0000000000001729

Jared J Tuttle, Shannon D Scarboro, John C Fitzpatrick, C Armitage Harper

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引用次数: 0

Abstract

Purpose: To describe a case of presumed MMC-induced retinal toxicity following combined cataract and Xen gel stent surgery.

Methods: Observational case report.

Results: A 66-year-old male presents with progressive vision loss (20/25 baseline to light-perception (LP)) following combined cataract and Xen gel stent surgery in the left eye. The patient received 0.15 ml of 0.4 mg/ml of MMC via intra-tenon injection during the surgery. The patient reported severe eye pain following surgery which gradually resolved over time. Upon examination at post-operative day 41, vessel attenuation, sclerotic vessels, and optic nerve pallor are observed without any retinal hemorrhaging. At post-operative day 55, visual acuity remains at LP with a flat line electroretinogram. Outcomes remain consistent at postoperative day 125.

Conclusion: Care should be taken to avoid intraocular MMC, especially when administered via intra-tenon injection during combined cataract and Xen gel stent surgery.

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推测丝裂霉素c在白内障和Xen凝胶支架联合手术后引起视网膜毒性。

目的：报告一例推测为mmc所致的白内障和Xen凝胶支架联合手术后视网膜毒性。方法：观察性病例报告。结果：66岁男性患者在左眼白内障和Xen凝胶支架联合手术后出现进行性视力丧失（20/25基线光感（LP））。术中患者通过肌腱内注射0.4 mg/ml的MMC 0.15 ml。患者报告术后严重的眼痛，随时间逐渐消退。术后第41天检查，血管衰减，血管硬化，视神经苍白，未见视网膜出血。术后第55天，视网膜电图平线显示视力维持在LP。术后125天的结果保持一致。结论：在白内障和Xen凝胶支架联合手术中，应注意避免眼内MMC，特别是通过腱内注射给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retinal Cases and Brief Reports Medicine-Ophthalmology

CiteScore

2.10

自引率

0.00%

发文量

342