Fabiola Reis de Oliveira, Simone Appenzeller, Sandra Gofinet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhães Souza Fialho, Aysa Cesar Pinheiro, Laura Caldas Dos Santos, Valeria Valim, Erica Vieira Serrano, Sandra Lucia Euzébio Ribeiro, Tatiana Nayara Libório-Kimura, Danielle Christinne Soares do Egypto, Diego Ustárroz Cantali, Juliana D'Agostino Gennari, Samira Tatiyama Miyamoto, Karina Gatz Capobianco, Alisson Aliel Vigano Pugliesi, Vinicius Tassoni Civile, Ana Carolina Pereira Nunes Pinto, César Ramos Rocha-Filho, Aline Pereira da Rocha, Virginia Fernandes Moça Trevisani
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引用次数: 0
Abstract
Background: Neurological and psychiatric manifestations occur in patients with primary Sjogren's disease (SjD) with a wide-ranging clinical presentation, affecting quality of life, social participation, and prognosis. Despite this, neither central nor peripheral neurological symptoms are systematically evaluated in the context of autoimmunity or identified as manifestations of SjD. The EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) covers only part of them in the neurological domain.
Methods: We performed a systematic review of the diagnosis and prevalence of central, peripheral, and autonomic nervous system manifestations in primary SjD, following the recommendations proposed by the Cochrane Collaboration Handbook. Observational studies were included when their main issue was the diagnosis and the prevalence of the manifestations individually. We employed a generalized linear mixed model (GLMM) method with a random-effects model, and the results were computed using logit transformation, implemented through the 'meta' and 'metafor' packages in the R software (version 3.6.1). To present these recommendations, agreement among experts was investigated using the Delphi method in in-person meetings.
Results: We propose ten recommendations regarding the investigation and management of neurological involvement in SjD that had 100% agreement among participants.
Conclusion: These recommendations add to the literature on the clinical care of patients with SjD.
期刊介绍：
Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication.
Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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