Hypothyroidism is a risk factor for transient ischemic attack: A meta-analysis.

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Jian Li, Hui Liu, Yan Li
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引用次数: 0

Abstract

Objectives: To evaluate whether hypothyroidism is a risk factor for transient ischemic attack (TIA).

Methods: We systematically searched Embase, PubMed, Cochrane, Vipers database, China Biomedical Literature Database, Wanfang Data, and China National Knowledge Infrastructure for studies assessing the association between hypothyroidism and TIA (publication cut-off in May 2024). Two researchers independently extracted the data based on inclusion and exclusion criteria. Meta-analysis was carried out using Review Manager 5.3 software.

Results: A total of 7 studies (combined n=190248) were included. Hypothyroidism showed a significant association with TIA (risk ratio [RR]=1.43 [95% confidence interval [CI]: [1.29-1.57]). The association was significant in clinical hypothyroidism (RR=1.45 [95% CI: [1.31-1.62]) but not evident in subclinical hypothyroidism (RR=1.20 [95% CI: [0.90-1.61]). Sensitivity analysis confirmed the stability and reliability of the results from the 7 studies (Begg's test z=1.2, p<0.01). No significant publication bias was detected in the meta-analysis.

Conclusion: Hypothyroidism, particularly clinical hypothyroidism, may be an independent risk factor for TIA.PROSPERO No. ID: CRD42024552608.

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来源期刊
Saudi Medical Journal
Saudi Medical Journal 医学-医学:内科
CiteScore
2.30
自引率
6.20%
发文量
203
审稿时长
12 months
期刊介绍: The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.
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