Invasive Aspergillosis Caused by Cryptic Species in Transplant Recipients: A Review.

IF 2.7 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2025-02-11 DOI:10.1093/mmy/myaf015

Muneyoshi Kimura, Shahid Husain

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引用次数: 0

Abstract

The clinical and microbiological characteristics of invasive aspergillosis (IA) caused by cryptic Aspergillus species have not been well-defined in transplant settings. However, IA is among the most common mold infections in solid organ and hematopoietic stem cell transplant recipients. Among 55 causative isolates in the 53 reported cases, A. calidoustus, A. lentulus, A. tubingensis, and A. udagawae were the four most common causative cryptic Aspergillus species. Newer diagnostic modalities, such as matrix-assisted laser desorption ionization-time of flight mass spectrometry, may help diagnose these cryptic species. Of the 24 cases with detailed clinical information, 13 had antifungal breakthrough infections. The 12-week mortality rates of all 24 cases, 7 cases of A. calidoustus and 7 cases of A. lentulus were 46%, 43% and 43%, respectively. Based on antifungal susceptibility profiles obtained from previous studies, an empiric antifungal regimen such as liposomal amphotericin B with or without echinocandin is recommended for A. calidoustus. A combination of an anti-mold azole and liposomal amphotericin B with or without an echinocandin is suggested for A. lentulus and A. udagawae. Additionally, any one of voriconazole, isavuconazole or posaconazole with or without liposomal amphotericin B with or without an echinocandin is indicated for A. tubingensis. Newer antifungal agents may have more significant activity against Aspergillus cryptic species.

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.