Liman Li, Nenggang Jiang, Yongmei Jin, Chuan Yang, Yang Fu
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引用次数: 0
Abstract
The immune response goes haywire during sepsis. The aim of this study was to explore the role of CD57+γδ T cells in the immune pathogenesis of sepsis. We characterized the transcriptomic profile of peripheral γδ T cells obtained from patients with sepsis using the Smart RNA-Sequence. We also analyzed the cell count and the immune functional signatures of CD57+γδ T cells in sepsis using flow cytometry. Besides, the cytotoxicity capacity of CD57+γδ T cell subset and its responses to sepsis-related drug were validated in vitro. Here, we found that patients with sepsis exhibited a reduction in peripheral CD57+γδ T cells proportion, which was positively associated with clinical outcomes. Compared with CD57-γδ T cells, CD57+γδ T cells exhibited drastically altered immunophenotype, including decreased expression levels of costimulatory molecules, higher expression levels of pro-inflammatory factors and cytotoxic granules.
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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