Effect of Aspirin on Biomarkers of Barrett's Esophagus After Successful Eradication with Radiofrequency Ablation.

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases and Sciences Pub Date : 2025-02-11 DOI:10.1007/s10620-025-08908-0

Robert S Bresalier, Nicholas J Shaheen, Mike Hernandez, Navtej Buttar, Norman Marcon, Sachin Wani, Raman Muthusamy, Gary Falk, Tamara Tipps Johnson, Peiying Yan, Xiaofang Huo, Tawana A Castille, Gary Della'Zanna, Ellen Richmond, J Jack Lee, Powel Brown, Rhonda Souza

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引用次数: 0

Abstract

Objectives/methods: Placebo-controlled phase II study evaluated aspirin's effect on CDX2 mRNA and prostanoid production in native and neosquamous epithelium after successful radiofrequency ablation (RFA) in Barrett's esophagus.

Results: At 12 months TXB2, PGF2α, PGD2, PGE2, PGE1, and α13PGE2 increased in native squamous but not neosquamous epithelium in individuals randomized to placebo. Aspirin use significantly reduced CDX2 mRNA in native squamous epithelium, and was associated with decreases in PGE1, PGE2 and 13PGE2 in neosquamous epithelium.

Conclusions: After RFA, native squamous and neosquamous epithelium exhibit different molecular markers and responses to aspirin suggesting that different sources of squamous progenitors contribute to esophageal re-epithelization.

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来源期刊

Digestive Diseases and Sciences 医学-胃肠肝病学

CiteScore

6.40

自引率

3.20%

发文量

420

审稿时长

1 months

期刊介绍： Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.