The current state of imaging biomarker development and evaluation.

IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Steve Halligan, Sue Mallett
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引用次数: 0

Abstract

With a focus on imaging, this narrative review describes why biomarker research rarely culminates in anything clinically useful. We explain the difference between diagnostic and prognostic biomarkers and the different phases of their research. We describe what factors need consideration when designing research studies to generate evidence sufficient to translate a potential imaging biomarker into clinical practice. We emphasise the need to balance the number of biomarkers investigated with the number of available patient events, so that studies are not overwhelmed by false-positive results. We explain the need for rigorous evaluation, so that clinicians can be convinced the biomarker will work in their practice and benefit their patients. In particular, we explain why novel biomarkers should be evaluated alongside factors already known to be clinically useful, so that their incremental benefit, if any, can be determined.

影像生物标志物的开发与评价现状。
以成像为重点,这篇叙述性综述描述了为什么生物标志物研究很少在任何临床有用的事情上达到高潮。我们解释了诊断和预后生物标志物之间的差异及其研究的不同阶段。我们描述了在设计研究时需要考虑哪些因素,以产生足够的证据,将潜在的成像生物标志物转化为临床实践。我们强调需要平衡研究的生物标志物数量与可用患者事件的数量,以便研究不会被假阳性结果所淹没。我们解释了严格评估的必要性,以便临床医生能够确信生物标志物将在他们的实践中起作用并使他们的患者受益。特别是,我们解释了为什么新的生物标志物应该与已知的临床有用因素一起评估,以便确定它们的增量效益(如果有的话)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Radiology
British Journal of Radiology 医学-核医学
CiteScore
5.30
自引率
3.80%
发文量
330
审稿时长
2-4 weeks
期刊介绍: BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option
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