Effect of Glucagon-Like Peptide-1 Receptor Agonists on Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis.

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-02-12 DOI:10.14309/ajg.0000000000003362

Azizullah Beran, Tarek Nayfeh, Aya Akhras, Daryl Ramai, Mouhand Mohamed, John J Guardiola, Mohammad Al-Haddad, Douglas K Rex

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引用次数: 0

Abstract

Introduction: The impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on colonoscopy bowel preparation is unclear.

Methods: We searched multiple databases for studies comparing bowel preparation quality between GLP-1RA users and control group. Using a random-effects model, we calculated pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs). Inadequate bowel preparation (IBP) rate was the primary outcome and Boston Bowel Preparation Scale (BBPS) mean score was the secondary outcome.

Results: Five studies with 10,833 subjects (n=5,434 GLP-1RAs vs. n=5,399 control) were included. The IBP rate was higher in the GLP-1RAs group compared to the control group (OR 2.10, 95% CI 1.41-3.13, p=0.0003). Furthermore, the mean BBPS score was lower in the GLP1-RAs group compared to the control group (MD -0.34; 95% CI -0.51, -0.17; p=0.0001).

Conclusions: Our findings suggest that using GLP-1RA increases the risk of inadequate bowel preparation.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.