The Impact of Pain on Everyday Activities of People With Hypermobility Spectrum Disorders or Hypermobility Ehlers Danlos Syndrome

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2025-02-13 DOI:10.1002/ejp.70000

Susanne Lindholm, Suzanne Petersson, Peter Molander, Mathilda Björk

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Abstract

Background

This study describes aspects of pain and how pain affects everyday life and examines the relation between chronic pain and activity limitations in people with hypermobility spectrum disorders (HSD) or hypermobility Ehlers Danlos syndrome (hEDS).

Methods

This cross-sectional study used data from 2016 to 2021 obtained from the Swedish quality registry for pain rehabilitation (SQRP), comparing those with HSD/hEDS with the larger group of people with mixed chronic pain conditions as a reference group (RG).

Results

Of the 43,801 people registered in the SQRP, 1211 (2.8%) were diagnosed with HSD/hEDS (88.9% women). The mean age of the HSD/hEDS group was younger (36.3 ± 11.8) than the RG (45.7 ± 12.8). The HSD/hEDS group had a statistically significant (p < 0.001) earlier onset of pain (calculated in years) in contrast to the RG. In the HSD/hEDS group, 80.1% had persistent pain; in the RG, 74.2% had persistent pain. The HSD/hEDS group reported more pain locations (20.0 ± 7.9) than the RG (14.8 ± 8.8). The HSD/hEDS group reported more problems performing leisure, social, and household activities than the RG; however, pain intensity was statistically significantly lower (p < 0.001) in the HSD/hEDS related to the RG.

Conclusions

There were indications that pain affected daily activities for people with HSD/hEDS, who had earlier onset of pain, marked more pain locations, and had more persistent pain, but pain intensity was not as decisive in contrast to the RG.

Significance Statement

In a comparison yielding statistically significant results (p < 0.001), persons with hypermobility spectrum disorder (HSD) or hypermobility Ehlers-Danlos syndrome (hEDS) reported earlier pain onset, longer pain durations, and a greater number of pain locations but surprisingly, lower pain intensity than the reference group which consisted of a mixed group of pain conditions. These pain characteristics affected daily activities, indicating a substantial impact on daily life for those with HSD/hEDS.

Abstract Image

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疼痛对多动谱系障碍或多动Ehlers - Danlos综合征患者日常活动的影响

本研究描述了疼痛的各个方面以及疼痛如何影响日常生活，并探讨了患有多动性谱系障碍（HSD）或多动性Ehlers Danlos综合征（hEDS）的人的慢性疼痛和活动限制之间的关系。方法：本横断面研究使用瑞典疼痛康复质量登记处（SQRP） 2016年至2021年的数据，将HSD/hEDS患者与较大的混合慢性疼痛患者组（RG）进行比较。结果在SQRP登记的43,801人中，1211人（2.8%）被诊断为HSD/hEDS（88.9%为女性）。HSD/hEDS组平均年龄（36.3±11.8）小于RG组（45.7±12.8）。与RG组相比，HSD/hEDS组的疼痛发作时间（以年计算）有统计学意义（p < 0.001）。在HSD/hEDS组中，80.1%的患者有持续性疼痛；在RG组，74.2%有持续性疼痛。HSD/hEDS组报告的疼痛部位（20.0±7.9）多于RG组（14.8±8.8）。HSD/hEDS组比RG组在休闲、社交和家庭活动中报告了更多的问题；然而，与RG相关的HSD/hEDS的疼痛强度在统计学上显著降低（p < 0.001）。结论：有迹象表明，疼痛对HSD/hEDS患者的日常活动有影响，他们的疼痛发作时间更早，疼痛部位更多，疼痛持续时间更长，但疼痛强度与RG相比并不是决定性的。在一项具有统计学意义的比较结果（p < 0.001）中，与由混合疼痛条件组成的参照组相比，患有多动性ehers - danlos综合征（hEDS）或多动性ehers - danlos综合征（HSD）的人报告的疼痛发作时间更早，疼痛持续时间更长，疼痛部位数量更多，但令人惊讶的是，疼痛强度更低。这些疼痛特征影响日常活动，表明对HSD/hEDS患者的日常生活有重大影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.