Facial fabrication of a hyperbranched poly-l-lysine (HBPL)-surfactant complex coating to inhibit catheter-associated infections

IF 6.5 2区材料科学 Q1 CHEMISTRY, APPLIED

Progress in Organic Coatings Pub Date : 2025-02-13 DOI:10.1016/j.porgcoat.2025.109132

Qi Chen , Linrui Liu , Shuaishuai Yuan , Zhibo Li

{"title":"Facial fabrication of a hyperbranched poly-l-lysine (HBPL)-surfactant complex coating to inhibit catheter-associated infections","authors":"Qi Chen , Linrui Liu , Shuaishuai Yuan , Zhibo Li","doi":"10.1016/j.porgcoat.2025.109132","DOIUrl":null,"url":null,"abstract":"<div><div>Insertion of a peritoneal dialysis (PD) catheter is one of the most common invasive procedures applied in treating chronic kidney disease. However, the PD catheter used in clinical practice is prone to bacterial adhesion and biofilm formation during peritoneal dialysis treatment. Therefore, endowing PD catheters with antibacterial properties and biocompatibility is urgently needed. Polypeptide-based antimicrobial agents have attracted increasing attention because they can combat multidrug-resistant microbes. In this work, we design two kinds of hyperbranched poly-<span>l</span>-lysine (HBPL) based coatings for catheters with arbitrary shapes. We demonstrated that the HBPL/isooctyl phosphate (IP) coating had strong antibacterial properties against <em>S. aureus</em>, while the HBPL/decanoic acid (DA) coating without C-N<sup>+</sup> showed no bactericidal properties. We showed that the HBPL/IP coated catheters can effectively inhibit the growth of bacteria under static or dynamic flow conditions. Moreover, hemolysis experiments revealed that all the coatings had low hemolytic activities (<0.5 %). For the <em>in vivo</em> experiment, the HBPL/IP coating showed excellent biocompatibility. Overall, the HBPL/IP coating shows great promise as a facial, stable, and effective antibacterial coating to treat catheter-associated infections.</div></div>","PeriodicalId":20834,"journal":{"name":"Progress in Organic Coatings","volume":"201 ","pages":"Article 109132"},"PeriodicalIF":6.5000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Organic Coatings","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300944025000815","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Insertion of a peritoneal dialysis (PD) catheter is one of the most common invasive procedures applied in treating chronic kidney disease. However, the PD catheter used in clinical practice is prone to bacterial adhesion and biofilm formation during peritoneal dialysis treatment. Therefore, endowing PD catheters with antibacterial properties and biocompatibility is urgently needed. Polypeptide-based antimicrobial agents have attracted increasing attention because they can combat multidrug-resistant microbes. In this work, we design two kinds of hyperbranched poly-l-lysine (HBPL) based coatings for catheters with arbitrary shapes. We demonstrated that the HBPL/isooctyl phosphate (IP) coating had strong antibacterial properties against S. aureus, while the HBPL/decanoic acid (DA) coating without C-N⁺ showed no bactericidal properties. We showed that the HBPL/IP coated catheters can effectively inhibit the growth of bacteria under static or dynamic flow conditions. Moreover, hemolysis experiments revealed that all the coatings had low hemolytic activities (<0.5 %). For the in vivo experiment, the HBPL/IP coating showed excellent biocompatibility. Overall, the HBPL/IP coating shows great promise as a facial, stable, and effective antibacterial coating to treat catheter-associated infections.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Progress in Organic Coatings 工程技术-材料科学：膜

CiteScore

11.40

自引率

15.20%

发文量

577

审稿时长

48 days

期刊介绍： The aim of this international journal is to analyse and publicise the progress and current state of knowledge in the field of organic coatings and related materials. The Editors and the Editorial Board members will solicit both review and research papers from academic and industrial scientists who are actively engaged in research and development or, in the case of review papers, have extensive experience in the subject to be reviewed. Unsolicited manuscripts will be accepted if they meet the journal''s requirements. The journal publishes papers dealing with such subjects as: • Chemical, physical and technological properties of organic coatings and related materials • Problems and methods of preparation, manufacture and application of these materials • Performance, testing and analysis.