Microfluidic platform for alcoholic fermentation process: Ethanol production and on-line quantification

IF 3.7 3区工程技术 Q2 ENGINEERING, CHEMICAL

Chemical Engineering Research & Design Pub Date : 2025-02-01 DOI:10.1016/j.cherd.2025.01.046

Mariana G.M. Lopes , Vania Silverio , Harrson S. Santana , Osvaldir P. Taranto

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Abstract

A microfluidic platform for alcoholic fermentation process can consist of a millireactor for the ethanol production and a microsensor for ethanol detection. Millireactors with immobilized yeast were previously developed and reached an average ethanol production of 1.42 % (v/v). The objective of this study was to develop and fabricate an ethanol microsensor and integrate it into a microfluidic platform. The microsensor composed of an ethanol-responsive membrane was manufactured using xurography and the sealing of Polydimethylsiloxane (PDMS) with the polymeric membrane were performed. Polyethersulfone (PES) membrane characteristics such as the number and size of pores and the dispersion of the Poly(N-isopropylacrylamide) (PNIPAM) nanogels were investigated. In the permeate flow tests the microsensors showed an increase in permeability with increasing ethanol concentration. The integration of the microfluidic platform was performed using a millireactor and a microsensor that were coupled to perform the fermentation process and monitor ethanol production. The sensor was able to measure an ethanol concentration of 1.97 % (v/v) for the collected samples in the millireactor. Therefore, it is possible to integrate, manufacture, and operate a microfluidic platform composed of the millireactor and the ethanol microsensor for the production and quantification of alcoholic fermentation.

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来源期刊

Chemical Engineering Research & Design 工程技术-工程：化工

CiteScore

6.10

自引率

7.70%

发文量

623

审稿时长

42 days

期刊介绍： ChERD aims to be the principal international journal for publication of high quality, original papers in chemical engineering. Papers showing how research results can be used in chemical engineering design, and accounts of experimental or theoretical research work bringing new perspectives to established principles, highlighting unsolved problems or indicating directions for future research, are particularly welcome. Contributions that deal with new developments in plant or processes and that can be given quantitative expression are encouraged. The journal is especially interested in papers that extend the boundaries of traditional chemical engineering.