Genomics analysis of Vreelandella piezotolerans V23 reveals its role in D-amino acids metabolism

IF 1.3 4区生物学 Q4 GENETICS & HEREDITY

Marine genomics Pub Date : 2025-02-12 DOI:10.1016/j.margen.2025.101179

Dan Liu, Tie-Ji Gu, Hou-Qi Wang, Ze-Kun Liu, Meng-Qi Wang, Jing-Li Lü, Xin-Yi Wang, Peng Wang, Chen Wang

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引用次数: 0

Abstract

D-amino acids are generally supposed to be unique metabolites existing only in bacteria. They can not only modify the bacterial cell wall and promote plant growth, but also participate in the immune regulation of mammals, which is of great significance in nature. Vreelandella piezotolerans V23, a Gram-negative and aerobic bacterium, was isolated from coastal seawater of the Yellow Sea, China. Here, we report the genome of strain V23 and its genomic characteristics to utilize D-amino acids. The genome of strain V23 consists of a single circular chromosome with a size of 3,926,051 bp and a GC content of 58.11 %. Genomic analysis revealed that strain V23 possessed various genes responsible for D-amino acids metabolism and a pathway of synthesizing peptidoglycan from D-amino acids. The results indicated that strain V23 has the capacity to utilize D-amino acids. And strain V23 has been confirmed to be able to grow up with different D-amino acids as the sole nitrogen source. This study also enhances our understanding of the physiological and metabolic characteristics, interspecific diversity of strains of Vreelandella genus, and provides a crucial foundation for further investigation of D-amino acids metabolism.

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对压耐受性V23的基因组学分析揭示了其在d -氨基酸代谢中的作用

d -氨基酸通常被认为是只存在于细菌中的独特代谢物。它们不仅能修饰细菌细胞壁，促进植物生长，还能参与哺乳动物的免疫调节，在自然界中具有重要意义。从黄海沿岸海水中分离出一种革兰氏阴性好氧细菌——压耐受性V23。本文报道了菌株V23的基因组及其利用d -氨基酸的基因组特征。菌株V23基因组由一条单圆形染色体组成，全长3,926,051 bp， GC含量为58.11%。基因组分析表明，菌株V23具有多种与d -氨基酸代谢有关的基因和一条d -氨基酸合成肽聚糖的途径。结果表明，菌株V23具有利用d -氨基酸的能力。菌株V23已被证实能够以不同的d -氨基酸作为唯一的氮源生长。本研究也为进一步了解Vreelandella属菌株的生理代谢特性和种间多样性，为进一步研究d -氨基酸代谢提供了重要的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine genomics 生物-遗传学

CiteScore

3.60

自引率

5.30%

发文量

审稿时长

29 days

期刊介绍： The journal publishes papers on all functional and evolutionary aspects of genes, chromatin, chromosomes and (meta)genomes of marine (and freshwater) organisms. It deals with new genome-enabled insights into the broader framework of environmental science. Topics within the scope of this journal include: • Population genomics and ecology • Evolutionary and developmental genomics • Comparative genomics • Metagenomics • Environmental genomics • Systems biology More specific topics include: geographic and phylogenomic characterization of aquatic organisms, metabolic capacities and pathways of organisms and communities, biogeochemical cycles, genomics and integrative approaches applied to microbial ecology including (meta)transcriptomics and (meta)proteomics, tracking of infectious diseases, environmental stress, global climate change and ecosystem modelling.