Chemical constituents from the stems of Ephedra intermedia and their α-glucosidase and AChE inhibitory effects

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-10 DOI:10.1016/j.fitote.2025.106433

Ying Niu , Yan-Ling Liu , Yan-Gang Cao , Yi-Xin Zhao , Xu Chen , Di Lu , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng

引用次数: 0

Abstract

Five undescribed glycosides (1–5) and eight known compounds (6–13) were isolated from the stems of Ephedra intermedia. Their chemical structures were determined by analysis of NMR, ECD, and MS data. In addition, The in vitro bioactive assay, α-glucosidase and acetylcholinesterase (AChE) inhibitory activities, suggested that compounds 11 and 12 exhibited obvious inhibitory effects on α-glucosidase with the IC₅₀ value of 49.51 ± 0.97 μM and 47.12 ± 0.98 μM, respectively, compounds 4 and 5 showed weak inhibitory effects on AChE at the concentration of 100 μM.

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中间麻黄茎中的化学成分及其α-葡萄糖苷酶和 AChE 抑制作用

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.