The anti-aging and anti-Alzheimer's disease potential of kinsenoside prepared from Anoectochilus roxburghii

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-11 DOI:10.1016/j.fitote.2025.106441

Xin Yuan , He Ni , Fan Shi , Yan-bo Huang , Yi Hou , Song-Qing Hu

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Abstract

Anoectochilus roxburghii is a high-value plant resource for nutraceutical efficacy and medicinal applications, among which kinsenoside is recognized as the main bioactive glycoside. However, the anti-aging and anti-Alzheimer's disease (AD) activities of kinsenoside have long been neglected. The objective of this study was to investigate the influences of kinsenoside on aging and amyloid-β (Aβ) proteotoxicity and underlying molecular mechanisms in Caenorhabditis elegans (C. elegans). Kinsenoside (50 μM) could significantly prolong the mean lifespan of C. elegans by 26.3 %. Moreover, it improved the physiological functions, stress resistance and in vivo antioxidant activities of C. elegans. Further studies indicated that kinsenoside upregulated the mRNA expression levels of aging-associated genes including sir-2.1, hsp-16.2, sek-1, skn-1, sod-3, hsf-1, gst-4. The genetic studies and molecular docking studies supported that SKN-1 and HSF-1 transcription factors were requirements for the kinsenoside-mediated longevity. Furthermore, kinsenoside could exert a protective effect on Aβ-induced proteotoxicity by regulating stress-responsive and autophagy-related genes in C. elegans CL4176. The results sheds light on the bioactive properties and pharmaceutical potential of kinsenoside including anti-aging and anti-AD, broadening the prospects of kinsenoside for industrial applications.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.